General Information of Drug-Metabolizing Enzyme (DME) (ID: DER7IAK)

DME Name Alpha-hydroxysteroid dehydrogenase (12AH)
Synonyms Hydroxysteroid dehydrogenase alpha; 12-alpha-HSD; 12-alpha-hydroxysteroid dehydrogenase; 12AH; HSD12A
Gene Name 12AH
UniProt ID
12AH_CLOS4
INTEDE ID
DME1751
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number EC: 1.1.1.176
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.176
Lineage Species: Clostridium hylemonae
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Lachnoclostridium
Species: Clostridium hylemonae
Tissue Distribution Primarily distributed in human gut.
Sequence
MIFDGKVAIITGGGKAKSIGYGIAVAYAK
Function This enzyme catalyzes the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated form. Abd it also acts on bile alcohols.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Oxolithocholic acid DMRKA08 N. A. N. A. Investigative [1]

References

1 Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18.