Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DER8TO2)

• DME Name: Beta-fructofuranosidase (BFRU)
• Synonyms: Sucrose-6-phosphate hydrolase; Invertase; scrB; LSJ_0102c
• Gene Name: scrB
• UniProt ID: A0A089QDN8_9LACO
• INTEDE ID: DME1712
• EC Number:
  EC: 3.2.1.26
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.26
• Lineage:
  Species: Lactobacillus fermentum
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Lactobacillaceae
  Genus: Lactobacillus
  Species: Lactobacillus fermentum
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MEWTRESRYKKYSEWDAETLLKLQAQATASKYQMSYHIRPQSGLLNDPNGFSYFNDEYHV
  FYQSYPFGAVHGLKSWVHLTSPDLVHWKNLGLAINADTKYDSHGAYSGSARVIDDKLFLM
  YTGNHRSKEWVRYPYQIGAIMDKDNNITKLDKPMIEPVDHITEHFRDPQLLKHRDEYFVI
  LGAQDAETKTGKISLFRSKDLKNWQDLGYLDFTEEEMGYMVECPNLVFIDDQPVLIFCPQ
  GLDKKVADYENIYPNMYIVGSNIRLDKAKFNTDQKAPLNLDDGFDVYATQAFTAPNGKAY
  AISWIGLPDISYPTDSENWANCLSQVKELSVVDGELYQRPVPAMASLREEGTLVRSEEVF
  DGQQIVHSAASKHYELKLDLTAGQNGKLFLAANKDLSQGIEIKFSTADDAFLTVDRSKAG
  IPFAEDYGTTRNIALPANKQLSLDIFVDGSVCEIFVNNGRHTLTLRFFAPDGNDKIAFIS
  DKKLQYTGTYWNMKNI
• Function: This enzyme takes part in glucuronoside catabolic process. Substrates include sucrose.
• KEGG Pathway:
  Biosynthesis of secondary metabolites (lsj01110)
  Galactose metabolism (lsj00052)
  Metabolic pathways (lsj01100)
  Starch and sucrose metabolism (lsj00500)

Molecular Interaction Atlas (MIA) of This DME

3 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[1]
Raffinose	DMVHDOS	N. A.	N. A.	Investigative	[1]
Stachyose	DM1R9GV	N. A.	N. A.	Investigative	[1]

References

• [1] Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8.