Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DERQS6E)

DME Name	Nicotinamidase (pncA)
Synonyms	Nicotinamide deamidase; Pyrazinamidase; Bifunctional protein; NAMase; PZAase; ABAYE0059; pncA
Gene Name	pncA
UniProt ID	B0VA03_ACIBY
INTEDE ID	DME1076
EC Number	EC: 3.5.1.19 Hydrolases Carbon-nitrogen hydrolase Linear amide hydrolase EC: 3.5.1.19
Lineage	Species: Acinetobacter baumannii Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Pseudomonadales Family: Moraxellaceae Genus: Acinetobacter Species: Acinetobacter baumannii
Tissue Distribution	Primarily distributed in human lung.
Sequence	MKMNKQPQNSALVVVDVQNGFTPGGNLAVADADTIIPTINQLAGCFENVVLTQDWHPDNH ISFAANHPGKQPFETIELDYGSQVLWPKHCIQGTHDAEFHPDLNIPTAQLIIRKGFHAHI DSYSAFMEADHTTMTGLTGYLKERGIDTVYVVGIATDFCVAWTALDAVKQGFKTLVIEDA CKGIDLNGSLEQAWQTMQQQGVVRIQSTDLLNEC
Function	This enzyme acts on carbon-nitrogen bonds and takes part in nicotinate and nicotinamide metabolism.
KEGG Pathway	Metabolic pathways (aby01100 ) Nicotinate and nicotinamide metabolism (aby00760 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[1]
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References

1	Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide. Angew Chem Int Ed Engl. 2009;48(48):9176-9.