Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DESDN74)

DME Name Serum paraoxonase/arylesterase 1 (PON1)
Synonyms Aromatic esterase 1; Serum aryldialkylphosphatase 1; A-esterase 1; PON 1; PON1; PON; K-45
Gene Name PON1
UniProt ID
PON1_HUMAN
INTEDE ID
DME0169
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
5444
EC Number EC: 3.1.1.2
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.2
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
Function
This enzyme hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. It is capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters.
Reactome Pathway
Synthesis of 5-eicosatetraenoic acids (R-HSA-2142688 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Loteprednol Etabonate DM8QTJI Eye inflammation 9A02 Approved [1]
Prulifloxacin DMOK965 Urinary tract infection GC08 Approved [2]
1 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
RTR-003632 DM45NHF N. A. N. A. Phase 2 [3]
6 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Coumaranone DM7TCPG N. A. N. A. Investigative [3]
Dihydrocoumarin DMGLX1R N. A. N. A. Investigative [3]
gamma-butyrolactone DMDCZWY Discovery agent N.A. Investigative [3]
Gamma-thiobutyrolactone DM83HUI N. A. N. A. Investigative [3]
Homogentisic acid DMQD0YW N. A. N. A. Investigative [3]
PARAOXON DMN4ZKC Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 6 Investigative Drug(s)
Experimental Enzyme Kinetic Data of Drugs
Drug Name Indication Highest Status Kinetic Data REF
gamma-butyrolactone Discovery agent [N.A.] Investigative Km = 15 microM [3]
PARAOXON Discovery agent [N.A.] Investigative Km = 0.27 microM [3]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.49E-03 2.10E-02 1.35E-01
Alopecia ED70 Skin from scalp 4.61E-02 1.69E-01 4.59E-01
Alzheimer's disease 8A20 Entorhinal cortex 8.24E-01 3.15E-03 2.07E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 6.80E-01 2.74E-02 2.65E-01
Aortic stenosis BB70 Calcified aortic valve 9.76E-01 1.42E-01 2.74E-01
Apnea 7A40 Hyperplastic tonsil 7.17E-02 1.09E-01 5.25E-01
Arthropathy FA00-FA5Z Peripheral blood 1.36E-01 2.59E-02 2.48E-01
Asthma CA23 Nasal and bronchial airway 2.37E-03 -7.71E-02 -2.18E-01
Atopic dermatitis EA80 Skin 9.82E-04 -6.54E-02 -6.07E-01
Autism 6A02 Whole blood 1.35E-01 -7.75E-02 -3.23E-01
Autoimmune uveitis 9A96 Peripheral monocyte 6.27E-01 -7.15E-02 -4.76E-01
Autosomal dominant monocytopenia 4B04 Whole blood 8.12E-01 8.89E-03 9.70E-02
Bacterial infection of gingival 1C1H Gingival tissue 4.19E-01 -2.08E-02 -9.48E-02
Batten disease 5C56.1 Whole blood 2.43E-02 1.81E-01 1.58E+00
Behcet's disease 4A62 Peripheral blood 3.76E-01 -5.87E-02 -2.93E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 8.57E-01 -3.86E-02 -3.54E-01
Bladder cancer 2C94 Bladder tissue 4.49E-03 5.00E-01 1.91E+00
Breast cancer 2C60-2C6Z Breast tissue 5.43E-01 -6.32E-02 -3.17E-01
Cardioembolic stroke 8B11.20 Whole blood 3.33E-04 1.12E-01 1.05E+00
Cervical cancer 2C77 Cervical tissue 6.33E-01 -1.28E-02 -4.68E-02
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.68E-01 -6.44E-03 -3.70E-02
Chronic hepatitis C 1E51.1 Whole blood 9.77E-01 3.73E-02 2.12E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 6.50E-02 5.33E-02 3.04E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 9.39E-01 -1.20E-02 -9.29E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.41E-01 -8.86E-03 -1.08E-01
Colon cancer 2B90 Colon tissue 2.89E-01 -6.69E-02 -3.65E-01
Coronary artery disease BA80-BA8Z Peripheral blood 4.76E-01 -9.53E-02 -4.83E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 2.58E-01 -4.50E-02 -2.62E-01
Endometriosis GA10 Endometrium tissue 1.32E-03 1.07E-01 7.30E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 3.65E-01 8.07E-03 7.40E-02
Familial hypercholesterolemia 5C80.00 Whole blood 1.32E-01 -6.51E-02 -2.98E-01
Gastric cancer 2B72 Gastric tissue 8.30E-01 -1.25E-01 -6.69E-01
Glioblastopma 2A00.00 Nervous tissue 1.87E-01 -1.71E-02 -8.56E-02
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 4.56E-01 -1.58E-03 -2.78E-02
Glioma 2A00.0Y-2A00.0Z White matter tissue 8.03E-03 -3.03E-01 -8.66E-01
Head and neck cancer 2D42 Head and neck tissue 3.79E-01 -1.59E-02 -1.20E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 9.27E-02 -2.17E-03 -7.94E-03
Huntington's disease 8A01.10 Whole blood 4.68E-03 1.08E-01 1.41E+00
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 8.07E-02 -2.88E-01 -1.05E+00
Immunodeficiency 4A00-4A20 Peripheral blood 1.60E-01 1.01E-01 9.41E-01
Influenza 1E30 Whole blood 9.98E-01 4.36E-02 2.99E-01
Interstitial cystitis GC00.3 Bladder tissue 5.79E-01 -8.24E-02 -5.13E-01
Intracranial aneurysm 8B01.0 Intracranial artery 2.10E-02 -8.08E-02 -5.05E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.85E-01 3.91E-02 9.82E-02
Ischemic stroke 8B11 Peripheral blood 2.51E-01 -1.09E-02 -7.99E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 1.50E-01 4.58E-02 2.47E-01
Lateral sclerosis 8B60.4 Skin 6.74E-01 -7.02E-02 -5.08E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 4.48E-01 -1.03E-03 -5.91E-03
Liver cancer 2C12.0 Liver tissue 9.81E-41 -1.71E+00 -3.14E+00
Liver failure DB99.7-DB99.8 Liver tissue 1.29E-03 -4.20E+00 -1.01E+01
Lung cancer 2C25 Lung tissue 1.65E-26 8.98E-02 4.13E-01
Lupus erythematosus 4A40 Whole blood 2.63E-01 -6.78E-02 -1.90E-01
Major depressive disorder 6A70-6A7Z Hippocampus 1.38E-01 -3.09E-02 -3.21E-01
Major depressive disorder 6A70-6A7Z Whole blood 4.70E-01 3.26E-02 1.72E-01
Melanoma 2C30 Skin 1.79E-05 -3.90E-01 -6.44E-01
Multiple myeloma 2A83.1 Peripheral blood 2.13E-01 9.14E-02 6.03E-01
Multiple myeloma 2A83.1 Bone marrow 3.03E-04 -5.54E-01 -2.48E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 8.47E-01 4.70E-03 2.10E-02
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 3.51E-02 3.77E-02 3.82E-01
Myelofibrosis 2A20.2 Whole blood 1.61E-01 6.48E-02 5.87E-01
Myocardial infarction BA41-BA50 Peripheral blood 7.72E-02 2.30E-01 4.66E-01
Myopathy 8C70.6 Muscle tissue 8.52E-01 -1.83E-02 -2.09E-01
Neonatal sepsis KA60 Whole blood 4.05E-01 4.59E-03 1.94E-02
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.80E-03 -2.92E-01 -1.27E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 4.09E-01 1.34E-01 2.12E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.94E-01 6.74E-02 8.36E-01
Olive pollen allergy CA08.00 Peripheral blood 1.97E-01 6.06E-02 4.39E-01
Oral cancer 2B6E Oral tissue 2.42E-03 -1.50E-01 -7.60E-01
Osteoarthritis FA00-FA0Z Synovial tissue 2.17E-01 6.78E-03 3.67E-02
Osteoporosis FB83.1 Bone marrow 2.87E-02 3.12E-01 6.23E+00
Ovarian cancer 2C73 Ovarian tissue 1.24E-01 -2.76E-01 -3.80E-01
Pancreatic cancer 2C10 Pancreas 7.47E-01 -2.15E-01 -9.30E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 6.73E-01 -1.29E-02 -1.08E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 9.13E-01 5.59E-03 5.63E-02
Pituitary cancer 2D12 Pituitary tissue 6.39E-01 -1.26E-01 -2.37E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 3.24E-01 -4.10E-02 -6.42E-02
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 1.24E-01 6.23E-02 6.47E-01
Polycythemia vera 2A20.4 Whole blood 1.39E-06 1.16E-01 1.10E+00
Pompe disease 5C51.3 Biceps muscle 3.32E-02 -1.30E-01 -9.42E-01
Preterm birth KA21.4Z Myometrium 2.27E-01 8.65E-02 7.72E-01
Prostate cancer 2C82 Prostate 1.39E-01 -4.30E-01 -5.32E-01
Psoriasis EA90 Skin 4.61E-05 8.98E-02 3.44E-01
Rectal cancer 2B92 Rectal colon tissue 4.33E-01 -3.56E-02 -2.03E-01
Renal cancer 2C90-2C91 Kidney 7.38E-02 -2.49E-01 -1.31E+00
Retinoblastoma 2D02.2 Uvea 9.38E-01 4.16E-02 2.90E-01
Rheumatoid arthritis FA20 Synovial tissue 2.61E-02 -1.47E-01 -7.36E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 7.68E-01 -1.66E-03 -1.42E-02
Schizophrenia 6A20 Prefrontal cortex 6.94E-01 -1.38E-02 -5.85E-02
Schizophrenia 6A20 Superior temporal cortex 1.35E-01 -8.43E-02 -8.43E-01
Scleroderma 4A42.Z Whole blood 7.47E-01 -2.22E-02 -1.95E-01
Seizure 8A60-8A6Z Whole blood 5.63E-01 -9.91E-02 -5.49E-01
Sensitive skin EK0Z Skin 7.99E-01 -3.86E-02 -3.95E-01
Sepsis with septic shock 1G41 Whole blood 9.15E-01 8.33E-04 3.12E-03
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.16E-01 3.11E-01 1.01E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 7.90E-01 1.39E-02 1.25E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 5.85E-01 5.33E-02 5.10E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 1.56E-01 6.36E-02 5.62E-01
Skin cancer 2C30-2C3Z Skin 2.42E-12 -2.02E-01 -5.80E-01
Thrombocythemia 3B63 Whole blood 6.16E-03 8.06E-02 7.50E-01
Thrombocytopenia 3B64 Whole blood 5.11E-01 6.99E-03 5.28E-02
Thyroid cancer 2D10 Thyroid 8.41E-01 2.12E-02 7.80E-02
Tibial muscular dystrophy 8C75 Muscle tissue 3.31E-01 2.51E-02 2.39E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.21E-01 9.86E-02 5.76E-01
Type 2 diabetes 5A11 Liver tissue 1.36E-01 2.67E-01 1.12E+00
Ureter cancer 2C92 Urothelium 1.17E-01 2.31E-01 1.15E+00
Uterine cancer 2C78 Endometrium tissue 2.81E-06 1.14E-01 5.27E-01
Vitiligo ED63.0 Skin 5.15E-01 -1.29E-01 -4.31E-01
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⏷ Show the Full List of DME Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name Serum paraoxonase/arylesterase 1 (PON1) DTT Info
DME DTT Type Literature-reported

References

1 Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol. 2017 Mar 1;127:82-89.
2 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
3 Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42.