Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DESN3MD)

DME Name Trans-L-3-hydroxyproline dehydratase (L3HYPDH)
Synonyms Trans-3-hydroxy-L-proline dehydratase; Transhydroxy-proline dehydratase; L3HYPDH; C14orf149
Gene Name L3HYPDH
UniProt ID
T3HPD_HUMAN
INTEDE ID
DME0550
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
112849
EC Number EC: 4.2.1.77
Lyases
Carbon-oxygen lyase
Hydro-lyase
EC: 4.2.1.77
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MESALAVPRLPPHDPGTPVLSVVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDH
VRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGL
VPAPPAGTREARVNIHCPCGLVTAFVACEDGRSHGPVRFHSVPAFVLATDLMVDVPGHGK
VMVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFL
YGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKS
SATGSVFTGKAVREAKCGDFKAVIVEVSGQAHYTGTASFIIEDDDPLRDGFLLK
Function
This enzyme catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). It may be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.
KEGG Pathway
Arginine and proline metabolism (hsa00330 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
AK-41099 DMQ90PJ N. A. N. A. Investigative [1]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.47E-08 2.38E-01 5.53E-01
Alopecia ED70 Skin from scalp 4.11E-03 9.67E-02 3.30E-01
Alzheimer's disease 8A20 Entorhinal cortex 4.44E-03 1.95E-01 5.01E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 9.51E-01 1.17E-01 4.06E-01
Aortic stenosis BB70 Calcified aortic valve 8.46E-01 1.97E-02 1.57E-02
Apnea 7A40 Hyperplastic tonsil 8.26E-02 -1.28E-01 -3.21E-01
Arthropathy FA00-FA5Z Peripheral blood 2.94E-01 -1.58E-01 -5.72E-01
Asthma CA23 Nasal and bronchial airway 2.43E-03 -2.26E-01 -3.74E-01
Atopic dermatitis EA80 Skin 2.29E-01 -2.37E-02 -5.91E-02
Autism 6A02 Whole blood 5.87E-02 7.46E-02 3.04E-01
Autoimmune uveitis 9A96 Peripheral monocyte 6.46E-01 1.84E-01 4.91E-01
Autosomal dominant monocytopenia 4B04 Whole blood 2.83E-02 -3.62E-01 -1.63E+00
Bacterial infection of gingival 1C1H Gingival tissue 1.25E-04 -2.06E-01 -6.53E-01
Batten disease 5C56.1 Whole blood 3.39E-01 -1.55E-01 -1.31E+00
Behcet's disease 4A62 Peripheral blood 4.54E-01 7.92E-02 2.36E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.58E-01 -4.27E-02 -1.71E-01
Bladder cancer 2C94 Bladder tissue 3.81E-01 -1.50E-01 -3.72E-01
Breast cancer 2C60-2C6Z Breast tissue 3.47E-12 -3.62E-01 -4.24E-01
Cardioembolic stroke 8B11.20 Whole blood 8.60E-02 3.05E-01 6.41E-01
Cervical cancer 2C77 Cervical tissue 8.63E-02 2.05E-01 6.12E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.30E-01 8.27E-02 1.11E-01
Chronic hepatitis C 1E51.1 Whole blood 1.97E-01 -1.11E-01 -2.70E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.64E-01 -1.48E-02 -3.82E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 5.69E-01 6.52E-02 1.29E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.61E-01 -7.32E-02 -3.44E-01
Colon cancer 2B90 Colon tissue 6.50E-45 4.82E-01 1.54E+00
Coronary artery disease BA80-BA8Z Peripheral blood 4.25E-01 2.31E-01 6.54E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 6.56E-01 3.65E-02 6.71E-02
Endometriosis GA10 Endometrium tissue 7.56E-01 -1.39E-02 -1.38E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 6.35E-01 -4.40E-02 -2.01E-01
Familial hypercholesterolemia 5C80.00 Whole blood 1.93E-04 5.99E-01 1.82E+00
Gastric cancer 2B72 Gastric tissue 1.14E-03 4.90E-01 6.43E+00
Glioblastopma 2A00.00 Nervous tissue 6.70E-77 7.03E-01 1.38E+00
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 2.66E-02 1.54E-01 4.29E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.96E-02 3.34E-01 4.86E-01
Head and neck cancer 2D42 Head and neck tissue 5.77E-13 4.79E-01 1.08E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 5.07E-01 9.56E-02 2.88E-01
Huntington's disease 8A01.10 Whole blood 4.41E-01 2.54E-01 7.30E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 4.72E-01 -5.11E-02 -1.72E-01
Immunodeficiency 4A00-4A20 Peripheral blood 5.26E-02 -2.45E-01 -1.15E+00
Influenza 1E30 Whole blood 5.22E-01 9.53E-03 8.85E-02
Interstitial cystitis GC00.3 Bladder tissue 3.77E-02 3.26E-01 1.39E+00
Intracranial aneurysm 8B01.0 Intracranial artery 4.77E-01 2.01E-01 4.40E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.78E-02 3.63E-02 1.31E-01
Ischemic stroke 8B11 Peripheral blood 8.71E-01 -4.04E-02 -1.00E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 9.91E-01 1.16E-01 1.90E-01
Lateral sclerosis 8B60.4 Skin 2.17E-01 1.36E-01 4.90E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.69E-01 3.57E-02 1.25E-01
Liver cancer 2C12.0 Liver tissue 7.67E-01 -3.14E-03 -5.58E-03
Liver failure DB99.7-DB99.8 Liver tissue 5.91E-05 -1.04E+00 -3.42E+00
Lung cancer 2C25 Lung tissue 2.31E-01 -1.16E-01 -2.88E-01
Lupus erythematosus 4A40 Whole blood 3.43E-04 2.80E-01 4.28E-01
Major depressive disorder 6A70-6A7Z Hippocampus 3.39E-01 -1.52E-02 -6.12E-02
Major depressive disorder 6A70-6A7Z Whole blood 4.54E-01 3.50E-03 1.40E-02
Melanoma 2C30 Skin 6.86E-01 3.49E-01 3.62E-01
Multiple myeloma 2A83.1 Peripheral blood 2.22E-01 1.32E-01 3.98E-01
Multiple myeloma 2A83.1 Bone marrow 4.12E-04 1.97E-01 1.72E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 9.16E-01 9.14E-03 2.84E-02
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 7.20E-02 -1.40E-02 -1.99E-02
Myelofibrosis 2A20.2 Whole blood 2.91E-02 -2.67E-01 -1.52E+00
Myocardial infarction BA41-BA50 Peripheral blood 1.70E-01 -2.51E-01 -3.74E-01
Myopathy 8C70.6 Muscle tissue 3.50E-01 1.03E-01 2.19E-01
Neonatal sepsis KA60 Whole blood 6.84E-01 -1.42E-01 -3.73E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.01E-01 9.64E-02 2.06E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 2.95E-01 -1.38E-01 -3.52E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 9.48E-01 -1.40E-01 -3.00E-01
Olive pollen allergy CA08.00 Peripheral blood 2.68E-01 -4.05E-01 -1.20E+00
Oral cancer 2B6E Oral tissue 1.78E-10 7.29E-01 1.63E+00
Osteoarthritis FA00-FA0Z Synovial tissue 4.21E-01 2.95E-01 2.84E-01
Osteoporosis FB83.1 Bone marrow 3.29E-01 1.93E-02 8.02E-02
Ovarian cancer 2C73 Ovarian tissue 4.17E-02 -2.50E-01 -8.56E-01
Pancreatic cancer 2C10 Pancreas 4.64E-03 4.61E-01 9.74E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 6.25E-01 1.28E-01 2.76E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 4.93E-01 2.08E-02 6.36E-02
Pituitary cancer 2D12 Pituitary tissue 1.14E-01 -4.92E-01 -1.25E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.23E-01 -3.24E-01 -1.00E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 7.47E-01 7.09E-03 4.06E-02
Polycythemia vera 2A20.4 Whole blood 1.22E-03 -1.67E-01 -8.32E-01
Pompe disease 5C51.3 Biceps muscle 1.50E-03 5.20E-01 1.33E+00
Preterm birth KA21.4Z Myometrium 4.09E-01 1.12E-01 3.20E-01
Prostate cancer 2C82 Prostate 2.74E-02 7.78E-01 7.91E-01
Psoriasis EA90 Skin 2.27E-08 2.27E-01 5.67E-01
Rectal cancer 2B92 Rectal colon tissue 5.18E-03 4.54E-01 1.51E+00
Renal cancer 2C90-2C91 Kidney 2.65E-02 4.42E-01 8.28E-01
Retinoblastoma 2D02.2 Uvea 1.43E-09 2.50E+00 8.86E+00
Rheumatoid arthritis FA20 Synovial tissue 1.24E-03 5.41E-01 1.45E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 3.26E-01 3.93E-02 1.01E-01
Schizophrenia 6A20 Prefrontal cortex 5.58E-01 1.27E-01 2.37E-01
Schizophrenia 6A20 Superior temporal cortex 6.16E-01 2.15E-02 1.08E-01
Scleroderma 4A42.Z Whole blood 2.74E-01 -1.81E-01 -8.48E-01
Seizure 8A60-8A6Z Whole blood 2.15E-01 9.80E-02 4.45E-01
Sensitive skin EK0Z Skin 3.08E-01 -1.90E-01 -7.78E-01
Sepsis with septic shock 1G41 Whole blood 6.41E-16 -3.42E-01 -1.03E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 5.54E-02 -3.58E-01 -8.28E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.43E-01 -3.12E-02 -9.89E-02
Simpson golabi behmel syndrome LD2C Adipose tissue 1.13E-01 -3.35E-01 -1.36E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 7.41E-01 4.82E-02 5.01E-01
Skin cancer 2C30-2C3Z Skin 2.12E-18 5.37E-01 1.19E+00
Thrombocythemia 3B63 Whole blood 4.34E-03 -1.98E-01 -1.14E+00
Thrombocytopenia 3B64 Whole blood 3.41E-01 -1.50E-01 -3.41E-01
Thyroid cancer 2D10 Thyroid 5.59E-05 -4.12E-01 -1.26E+00
Tibial muscular dystrophy 8C75 Muscle tissue 8.24E-01 2.41E-01 5.78E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.39E-01 3.72E-02 2.74E-01
Type 2 diabetes 5A11 Liver tissue 6.18E-01 9.73E-02 3.84E-01
Ureter cancer 2C92 Urothelium 4.34E-01 -6.25E-02 -4.16E-01
Uterine cancer 2C78 Endometrium tissue 2.16E-10 -5.36E-01 -9.69E-01
Vitiligo ED63.0 Skin 1.19E-01 2.37E-01 6.35E-01
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⏷ Show the Full List of DME Expression Under 107 Diseases

References

1 An enzymatic method to estimate the content of L-hydroxyproline. J Biotechnol. 2015 Apr 10;199:9-16.