Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DESOXHP)

DME Name VanA ligase (vanA)
Synonyms Vancomycin/teicoplanin A-type resistance protein VanA; D-alanylalanine synthetase VanA; D-alanine--D-alanine ligase VanA; D-Ala-D-Ala ligase VanA; NCTC4725_01016; vanA
Gene Name vanA
UniProt ID
A0A4U9YK96_ENTCA
INTEDE ID
DME1631
EC Number EC: 6.3.2.4
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage Species: Enterococcus casseliflavus
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus casseliflavus

Subspecies: Enterococcus casseliflavus BM4232
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKIAIIFGGNSPEYTVSLASATSAIEALQSSPYDYDLSLIGIAPDAMDWYLYTGELENI
RQDTWLLDTKHTQKIQPLFEGNGFWISEAQQTLVPDVLFPIMHGKYGEDGSIQGLFELMK
LPYVGCGVAASALCMNKWLLHQAAAAIGVQSAPTILLTNQANQQRQIEAFIQTHGFPVFF
KPNEAGSSKGITKVTCVEEIAPALKEAFAYCSAVLLQKNIAGVEIGCGILGNDSLTVGAC
DAISLVDGFFDFEEKYQLISAKITVPAPLPETIETKVKEQAQLLYHSLGLKGLARIDFFV
TDQGELYLNEINTMPGFTSHSRYPAMMAAVGLSYQELLQKLLVLAKEEGK
Function
This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6.3.2.7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6.3.2.13), UDP-N-acetylmuramate---L-alanine ligase (EC 6.3.2.8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6.3.2.9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6.3.2.10) in the synthesis of a cell-wall peptide.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [1], [2]
Vancomycin DM3JFIH Bacteremia 1A73 Approved [1], [2]

References

1 vanA in Enterococcus faecium, Enterococcus faecalis, and Enterococcus casseliflavus detected in French cattle. Foodborne Pathog Dis. 2009 Nov;6(9):1107-11.
2 Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7.