Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DETRKSD)

DME Name	Carbapenemase (cphA)
Synonyms	Versatile beta-lactamase; Versatile hydrolytic beta-lactamase; Beta-lactamase II; Carbapenem-hydrolyzing metallo-beta-lactamase; Metallo-beta-lactamase type 2b; Metallo-beta-lactamase type IIb; axc
Gene Name	axc
UniProt ID	A0A3G1JAD7_ALCXX
INTEDE ID	DME2021
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Achromobacter xylosoxidans Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Alcaligenaceae Genus: Achromobacter Species: Achromobacter xylosoxidans
Tissue Distribution	Primarily distributed in human stomach.
Sequence	MLTRRTFIASAVLAGWIPALAHARTDKKTRWTRESLAAFQQGLAQVEAASRGRLGVALLD VGSGQAAGYRADERFLMLSSFKTLSAAYVLARADRGEDQLSRRIPITDADVREYSPVTRL HVGPRGMTLAELCEATITTSDNAAVNLMHKSYGGPQALTRYLRSLGDTVTRHDRYEPELN RPHPSEPQDTTTPQAMARTLDTLLFGDALKPQSRQQLQSWLLANTTGGKRLRAGMPADWK IGEKTGTYSKVGCNDAGFAQPPGAAPIIIAAYLETTAVPMEERDRCIAEVGRLVAALG
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[1]
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References

1	Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans. Sci Rep. 2018 May 25;8(1):8181.