Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEW0GI5)
| DME Name | Folylpolyglutamate synthetase (fpgS) | ||||
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| Synonyms | Bacterial folylpoly-gamma-glutamate synthetase; Bacterial tetrahydrofolylpolyglutamate synthase; Folylpolyglutamate synthase; Bacterial FPGS; fpgS | ||||
| Gene Name | fpgS | ||||
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| 3D Structure | |||||
| EC Number | EC: 6.3.2.17 | ||||
| Lineage | Species: Lactobacillus casei | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MNYTETVAYIHSFPRLAKTGDHRRILTLLHALGNPQQQGRYIHVTGTNGKGSAANAIAHV
LEASGLTVGLYTSPFIMRFNERIMIDHEPIPDAALVNAVAFVRAALERLQQQQADFNVTE FEFITALGYWYFRQRQVDVAVIEVGIGGDTDSTNVITPVVSVLTEVALDHQKLLGHTITA IAKHKAGIIKRGIPVVTGNLVPDAAAVVAAKVATTGSQWLRFDRDFSVPKAKLHGWGQRF TYEDQDGRISDLEVPLVGDYQQRNMAIAIQTAKVYAKQTEWPLTPQNIRQGLAASHWPAR LEKISDTPLIVIDGAHNPDGINGLITALKQLFSQPITVIAGILADKDYAAMADRLTAAFS TVYLVPVPGTPRALPEAGYEALHEGRLKDSWQEALAASLNDVPDQPIVITGSLYLASAVR QTLLGGKS |
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| Function |
This enzyme is involved in the conversion of folates to polyglutamate derivatives, and likely functions in the retention of cellular folate pools. It catalyzes successive MgATP-dependent additions of glutamate to a pteroylmonoglutamate substrate, with a high preference for 5,10-methylenetetrahydrofolate (mTHF). Thus, it metabolizes mTHF to the tetraglutamate derivative, but longer glutamate chain length products are not observed.
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Molecular Interaction Atlas (MIA) of This DME
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1 Approved Drug(s) Metabolized by This DME
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