Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEWDJU4)

DME Name	Retinol dehydrogenase 14 (RDH14)
Synonyms	Dehydrogenase/reductase family 7C member 4; Alcohol dehydrogenase PAN2; Short chain dehydrogenase/reductase family 7C member 4; PAN2; RDH14; SDR7C4; UNQ529/PRO1072
Gene Name	RDH14
UniProt ID	RDH14_HUMAN
INTEDE ID	DME0472
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	57665
EC Number	EC: 1.1.1.300 Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.300
Lineage	Species: Homo sapiens Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Sequence	MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATA AELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLR SVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLK SSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNV TVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSG RYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK
Function	This enzyme has a clear preference for NADP. It displays high activity towards 9-cis, 11-cis and all-trans-retinol, a very weak activity towards 13-cis-retinol but no activity towards steroid.
Reactome Pathway	RA biosynthesis pathway (R-HSA-5365859 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NADH	DM5NM6E	Parkinson disease	8A00.0	Approved	[1]
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Experimental Enzyme Kinetic Data of Drugs

Drug Name	Indication	Highest Status	Kinetic Data	REF
NADH	Parkinson disease [8A00.0]	Approved	Km = 1200 microM	[1]

References

1	Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues. FEBS Lett. 2002 Nov 20;531(3):489-93.