Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEWP153)

DME Name	Hyaluronidase (hyl)
Synonyms	Chondroitin sulfate hydrolase; Hyaluronate lyase; Chondroitinase; Chondroitinase I; Cumulase; HYase; hyl; hysA
Gene Name	hyl
UniProt ID	W5RSC1_9BACI
INTEDE ID	DME1143
EC Number	EC: 4.2.2.1 Lyases Carbon-oxygen lyase Polysaccharide-lyase EC: 4.2.2.1
Lineage	Species: Bacillus megaterium Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Bacillaceae Genus: Bacillus Species: Bacillus megaterium
Tissue Distribution	Primarily distributed in human gut.
Sequence	NESTLLLNTSFEETEAPKSGWDQLGAPKWGVWRPTGSPIVTITKEASRTGEYGLKIAAAQ SARAAVSQDVPVQGGQTYQLGTWLKTDNIVSGQGARLRVVLYEGTQQLGLLYSSRLTGTH DWSQIKMEVKTPANADSIRVQLFFETGTGTALFDDVSLQLIQPATSIAIEESEITIKEQE TGLLHAQMVPADASSKVSWVSADPSIATVDNGKVTGVNPGGTTIMAFTDNGLAATSTVKV IKNDGIERPEVTQLDLQPKELELGSGQVRLLQAIIAPATADAEKLVWSSSNEAVASIQKG LIEAKASGTAVITVETEDGSLKSESQITVTDAVVDEYDQLRKKWKSLMTGLDSYDPTNVR MNEMIQNQTKSAETLWKTMFKNNDRSFLWINFASTDNSADIRDSYRNLTTMAKAFANEHS SLYRNPQLLKDITEALEWLYQNRYNESIAQYSNWWHWEIGVPNELNSLMVLLYDYLDQDS IHRYLKVVDHFQPDPTKSGATTPEKYREALGANRIDVSKVVGVRGVIVKDATKIAAARDA LSQTFENVTEGDGFYEDGSFVQHENIAYNGSYGIVLIEGLTDMLELLSNSTWQVTDPKVT NVYDWIETAYEPFMYKGALMDMVRGRAISRNFLQDHQAGHTIIKSVIRMAQFAPEPYAEK YNSMAKYWLQEDTYLDYFKNAGNFRDITLAKQLLEKQEVTPRGDLDFHKTFASMDRVVHR KSGYAFGISMYSNRIQNYEDMNDENRKGWYTGEGMTYLYNGDLAQYSDDFWPTVDPYRMP GTTVDTMRRADGSGEHRSSESWTGGSTLKNFGSAGMSYDAWNSSLIAKKSWFMFDNEIVA LGAGITSSEDRNVESIVENRKIRNDGSNQLVINGETLNLSNGGQNQTMAAKWAFLEGNVP GADIGYYFPEGKMLTIKKEERTGAWKDINYGGPAEAIKRSYTTMWFDHGVRPEQDTYSYV LLPGLNKEQTHQYSQNPDITILRNDSAVQAVQDVKENIIGANFWKDEKQSAGPLTVYQKA SVTMQEKDGVLEIAVCDPTMENKGSIEIEIDGKAFKVLEADESITVENTKPSIKLKVNVN EAKGKTFTAKLKMIPSQKGNSPNSIR
Function	This enzyme catalyzes the degradation of hyaluronan by a beta-elimination reaction and it also acts on chondroitin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hyaluronate sodium	DMX8M26	Joint lubricant	FA30-FA38	Approved	[1], [2]
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Experimental Enzyme Kinetic Data of Drugs

Drug Name	Indication	Highest Status	Kinetic Data	REF
Hyaluronate sodium	Joint lubricant [FA30-FA38]	Approved	Km = 20 microM	[1], [2]

References

1	A novel hyaluronidase produced by Bacillus sp. A50. PLoS One. 2014 Apr 15;9(4):e94156.
2	Intracellular oxidative damage due to antibiotics on gut bacteria reduced by glutathione oxidoreductase-derived antioxidant molecule GM15. Arch Microbiol. 2020 Feb 14.