Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEX2ZLF)

DME Name Tyrosine decarboxylase (tdc)
Synonyms Levodopa decarboxylase; L-dopa decarboxylase; L-tyrosine decarboxylase; TDC; tdc; tdcA; CNR29_12740; N624_0219; TDC; UCCLBBS449_2369
Gene Name tdc
UniProt ID
TYRDC_LACBR
INTEDE ID
DME1553
Gene ID
4413406
EC Number EC: 4.1.1.25
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.25
Lineage Species: Lactobacillus brevis
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus brevis
Tissue Distribution Primarily distributed in human gut.
Sequence
MEKSNRSLKDLDLNALFIGDKAENGQLYKDLLNKLVDEHLGWRKNYIPSDPNMIGPEDQN
SPAFKKTVGHMKTVLDQLSERIRTESVPWHSAGRYWGHMNSETLMPALLAYNYAMLWNGN
NVAYESSPATSQMEEEVGQEFARLMGYDYGWGHIVADGSLANLEGLWYARNIKSLPFAMK
EVNPELVAGKSDWELLNMPTKEIMDLLENAGSQIDEVKKRSARSGKNLQRLGKWLVPQTK
HYSWMKAADIIGIGLDQVVPVPIDSNYRMDIQALESIIRKYAAEKTPILGVVGVAGSTEE
GAVDGIDKIVALRQKLQKEGIYFYLHVDAAYGGYARALFLDEDDQFIPYKNLQKVHAENH
VFTEDKEYIKPEVYAAYKAFDQAESITIDPHKMGYVPYSAGGIVIQDIRMRDTISYFATY
VFEKGADIPALLGAYILEGSKAGATAASVWAAHHTLPLNVTGYGKLEGASIEGAHRYYDF
LKNLKFEVAGKRISVHPLISPDFNMVDYVLKEDGNDDLIEMNRLNHAFYEQASYVKGSLY
GKEYIVSHTDFAIPDYGDSPLAFVESLGFSEVEWRHAGKVTIIRASVMTPYMNQRENFDY
FAPRIKKAIQADLEKVYASVNQKENV
Function This enzyme catalyzes the decarboxylation of L-tyrosine to produce tyramine.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-tyrosine DM9O8DT Malnutrition 5B50-5B71 Approved [1]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [2]
Experimental Enzyme Kinetic Data of Drugs
Drug Name Indication Highest Status Kinetic Data REF
L-tyrosine Malnutrition [5B50-5B71] Approved Km = 590 microM [1]

References

1 Tyrosine decarboxylase from Lactobacillus brevis: soluble expression and characterization. Protein Expr Purif. 2014 Feb;94:33-9.
2 Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. Nat Commun. 2019 Jan 18;10(1):310.