Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEYIEO5)

• DME Name: Beta-lactamase (blaB)
• Synonyms: Penicillinase; Cephalosporinase; Beta-lactam; PAU_00771; PA-RVA13-1244
• Gene Name: ampC
• UniProt ID: AMPC_SERMA
• INTEDE ID: DME1231
• EC Number:
  EC: 3.5.2.6
  Hydrolases
  Carbon-nitrogen hydrolase
  Cyclic amide hydrolase
  EC: 3.5.2.6
• Lineage:
  Species: Serratia marcescens
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Enterobacterales
  Family: Yersiniaceae
  Genus: Serratia
  Species: Serratia marcescens
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MTKMNRCAALIAALILPTAHAAQQQDIDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGV
  ASKQTGKPITEQTLFEVGSLSKTFTATLAVYAQQQSKLSFKDPASHYLPDVRGSAFDGVS
  LLNLATHTSGLPLFVPDDVTNNAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSL
  DQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAESYGIKS
  NARDLIRYLDANLQQVKVASVARRWPRRTSVITSAGAFTQDLMWENYPYPVKLSRLIEGN
  NAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVEMLANKWFPND
  DRVEAAYHIIQALEKR
• Function: This enzyme hydrolyzes beta-lactam with a substrate specificity for cephalosporins.

Molecular Interaction Atlas (MIA) of This DME

5 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[1]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[1], [2]
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[3], [4]
Piperacillin	DMTBKF3	Acute gonococcal cervicitis		Approved	[1]
Tazobactam	DM3XNUI	Appendicitis	DB10	Approved	[1]

References

• [1] Determination of the antibiotic resistance rates of Serratia marcescens isolates obtained from various clinical specimens. Niger J Clin Pract. 2019 Jan;22(1):125-130.
• [2] Serratia marcescens is injurious to intestinal epithelial cells. Gut Microbes. 2014;5(6):729-36.
• [3] Antibiotic therapy for inducible AmpC beta-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides? Int J Antimicrob Agents. 2012 Oct;40(4):297-305.
• [4] Serratia marcescens producing SME carbapenemases: an emerging resistance problem in the UK? J Antimicrob Chemother. 2017 May 1;72(5):1535-1537.