Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEYM2D3)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; EUBIFOR_00490
Gene Name	blaB
UniProt ID	B7C8I6_9FIRM
INTEDE ID	DME1313
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Holdemanella biformis Kingdom: Bacteria Phylum: Firmicutes Class: Erysipelotrichia Order: Erysipelotrichales Family: Erysipelotrichaceae Genus: Holdemanella Species: Holdemanella biformis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MQNGKIVCADAIGVIDKINNQPITTDCTFNVCSISKIYCTVCIMQLVDEGLIQLEDKVAD ILPEFTMKDERYKDITVRMCLDHSSGLPGTQWKHFSVSTTSKFDYYSEVLNYFSNSTLKA DPGTYSTYCNDGFTLAEMVVSKVRNMPYEDVLKKYITEKIGAKSTNTTYTINSDCPLVSE GKKPKEYFPIQGAGGITTSMIDLCKFGQLFLEPNSIISEKSKTLMAKSWGTTFLESDLGA IDFGLGWDLVRHHDPDYDFGDGVLAKGGNSMFFSSRLIIVPKYNAVLAFSETHDCGLEVP TTLMRLFNTYLEPNTYPDYSGIYAHAFGLQKITTIKSSMVVQDKTEKGWIMSDLLNYSNG KWTNEKGNQIFFEGDYLLKTTRNRTGAFAQKAKKQELNSVWKSRLNKKYIVCDTTYYDIV TNQMLCSVEFNRTEDTLSLIVHGNKSEPVISEFPIEVIDDTHAKSYLNTPCNGSRDRIEP YFEDGKLYCASYTYICEDDIEPYNFQLFEKENQVYKINNTLEVLPTICENHRILVLDSNG DLYYDSMDVEEYKPIESGFIILV
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ceftiofur	DMR2SOZ	Bacterial infection	1A00-1C4Z	Approved	[1], [2]
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References

1	Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8.
2	Daily HIV pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate-emtricitabine reduced Streptococcus and increased Erysipelotrichaceae in rectal microbiota. Sci Rep. 2018 Oct 12;8(1):15212.