Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEZAQPD)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; blaP; ROTAS13_00836
Gene Name	blaP
UniProt ID	A0A1Q2YQ29_9PROT
INTEDE ID	DME2072
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Roseomonas gilardii Kingdom: Bacteria Phylum: Proteobacteria Class: Alphaproteobacteria Order: Rhodospirillales Family: Acetobacteraceae Genus: Roseomonas Species: Roseomonas gilardii
Tissue Distribution	Primarily distributed in human skin.
Sequence	MIGRRMGMGAMAALGLGMMAAGPSGARAASGAGKGQAGAGFSALPAVFAGIERRVGGRLG VAVLDTATGQRAGHREAERFPLTSTFKLLAAAAVLSRVDAGQARLDQRIRYGREKLVAYS PETEKHAGEEGMTLAAICEAAVTLSDNTAGNLMLEQIGGPAGLTAWLRSIGDTVTRLDRW ETALNEAEPGDPRDTTSPAAMLASLQRVTLGEALSVGGQAHLTGWLRANKTGDKRLRAGL PGGWQAGDKTGAGERGTNNDAGLLWPPGESAPILVAAYSTGGTAPSTERDAALAEVAAAI VAAKGP
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ceftiofur	DMR2SOZ	Bacterial infection	1A00-1C4Z	Approved	[1], [2]
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References

1	Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur. Vet Microbiol. 2009 Oct 20;139(1-2):89-96.
2	Skin microbiota is the main reservoir of Roseomonas mucosa, an emerging opportunistic pathogen so far assumed to be environmental. Clin Microbiol Infect. 2016 Aug;22(8):737.e1-7.