Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEZXOEW)

• DME Name: Beta-glucosidase (bglA)
• Synonyms: Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; BN702_00404
• Gene Name: BN702_00404
• UniProt ID: R5RU84_9BACE
• INTEDE ID: DME1477
• EC Number:
  EC: 3.2.1.21
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.21
• Lineage:
  Species: Bacteroides dorei
  Kingdom: Bacteria
  Phylum: Bacteroidetes
  Class: Bacteroidia
  Order: Bacteroidales
  Family: Bacteroidaceae
  Genus: Bacteroides
  Species: Bacteroides dorei
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MHSKQKGTFPTTPRILAAFLMAFFLMVSCGCSTKIGQPVLPDSEGNGSETETPDDNKPDE
  NKPGENEQTPDSEGYVLMWSDEFDSNSLDTGKWRIEVNGNGGGNAELQYYDESGISLGKD
  SEYGNSALKITAKREQRNGKAFVSGRLNTSGHFQFCYGKVEGRIRLPRTANGLWPAFWLL
  GADFQTNSWPRCGEIDIMEMGNAEGIKKGTQDRFFNGACHWGYYKGSAYPNYAHSTTNSY
  SIQDGNYHTYTLIWTPQSVKMYLDRDLHPNASPYYEMDIVNKDDDWGVGYYFHHNFFIIL
  NLAVGGYFTGILQPEGITALPNNGDSATMFVDWVRVYQKKQ
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[1]

References

• [1] Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100.