Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT08HOR5)

DOT Name	Superoxide dismutase (SOD2)
Synonyms	EC 1.15.1.1
Gene Name	SOD2
UniProt ID	Q4ZJI1_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	1.15.1.1
Pfam ID	PF02777 ; PF00081
Sequence	RHQQAAGRQAAWLPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNN LNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAI KRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLG IDVWEHAYYLQYKNVRPDYLKAIWNVINWENV
Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Paclitaxel	DMLB81S	Approved	Superoxide dismutase (SOD2) increases the Apoptosis ADR of Paclitaxel.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.