Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTBWIET3)

DOT Name	Putative claudin-25 (CLDN25)
Gene Name	CLDN25
UniProt ID	CLD25_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF00822
Sequence	MAWSFRAKVQLGGLLLSLLGWVCSCVTTILPQWKTLNLELNEMETWIMGIWEVCVDREEV ATVCKAFESFLSLPQELQVARILMVASHGLGLLGLLLCSFGSECFQFHRIRWVFKRRLGL LGRTLEASASATTLLPVSWVAHATIQDFWDDSIPDIIPRWEFGGALYLGWAAGIFLALGG LLLIFSACLGKEDVPFPLMAGPTVPLSCAPVEESDGSFHLMLRPRNLVI
Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
KEGG Pathway	Cell adhesion molecules (hsa04514 ) Tight junction (hsa04530 ) Leukocyte transendothelial migration (hsa04670 ) Pathogenic Escherichia coli infection (hsa05130 ) Hepatitis C (hsa05160 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Testosterone	DM7HUNW	Approved	Testosterone decreases the expression of Putative claudin-25 (CLDN25).	[1]
Maleic Acid	DM4L0R7	Investigative	Maleic Acid increases the expression of Putative claudin-25 (CLDN25).	[2]
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References

1	The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
2	Profiling transcriptomes of human SH-SY5Y neuroblastoma cells exposed to maleic acid. PeerJ. 2017 Apr 5;5:e3175.