Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTDXBZF8)

DOT Name Leucine-rich colipase-like protein 1 (LRCOL1)
Gene Name LRCOL1
UniProt ID
LRCL1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15083
Sequence
MAGPGWTLLLLLLLLLLLGSMAGYGPQKKLNLSHKGIGEPCRRHEECQSNCCTINSLAPH
TLCTPKTIFLQCLPWRKPNGYRCSHDSECQSSCCVRNNSPQELCTPQSVFLQCVPWRKPN
GDFCSSHQECHSQCCIQLREYSPFRCIPRTGILAQCLPL

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Propofol DMB4OLE Approved Propofol decreases the expression of Leucine-rich colipase-like protein 1 (LRCOL1). [1]
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References

1 Propofol suppresses proliferation, migration, invasion, and tumor growth of liver cancer cells via suppressing cancer susceptibility candidate 9/phosphatase and tensin homolog/AKT serine/threonine kinase/mechanistic target of rapamycin kinase axis. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211065972. doi: 10.1177/09603271211065972.