Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTFI7I9Z)

DOT Name	DNA gyrase subunit A (gyrA)
Synonyms	EC 5.6.2.2
Gene Name	gyrA
UniProt ID	GYRA_AERSA
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	5.6.2.2
Pfam ID	PF03989 ; PF00521
Sequence	MSDLAREITPINIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNELGNDWN KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRLAQDFSMRYMLVDGQGNFGSVDGDSAAAM RYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPNLLVNGSSGIAVGMAW NIPPHNLTEIVNGCLALIENGNLTIDELMTYITGPDFPTGAIINGRAGIVQAYRTGRGSV YVRAKAEVEVDDKTSRETIIIVHELPYQVNKARLIEKIAELVKEKKVEGISALRDESDKD ACRIVIEIKRGESGEIVLNNLYKHTQLQTTFGINMVALDNNQPKVMNLKDILDAFLLHRR EVVTRRTVFELRKARDRAHILEGLAVALANIDPIIELIRHSDTPADAKAKLVARGWELGN VAAMLEKAGDDAARPEWLEPEFGIREGQYFLTEQQAQAILDLRLHKLTGLEHGKILEEYQ SLLDLIAELLFILASPERLMEVIRDELLAVREQYGDERPPEISASSAEINIEDLITPEDV VVTLSHQGYVKYQPITDYEAQRRGGRGKSATRIKEENFVERLLVANTHDTILCFSTRGKV YWLKVYQLPEASRGARGRPIINLLPLEEGERITAILPVKEYADDKYVFFATADGTVKKTS LSAFSRPLSSGIRAINLKEGDELIGVDITDGSNEIMLFSDAGKVVRFNEGSAAPMQPMLM SSDDVDGDDESVIDAGNDDDGSDNGEGSESTESKGTFKGVRPMGRTAGGVRGIRLLNGDK VVSLIVPRGEGAILTATENGYGKGTALTEYPTKSRGTQGVRSIKVDEDGKVSIDQVDDTD QIMLITNGGTLVRTRVSEVSIIGRNTGGVRLIRTGEDETVVGLQRIAESYEEENDVMAID GEVSEGTDTAPDAGSAAADPEE
Function	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Ciprofloxacin XR	DM2NLS9	Approved	DNA gyrase subunit A (gyrA) increases the Death ADR of Ciprofloxacin XR.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.