Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTFZ5T2E)

DOT Name Spermatogenesis-associated protein 1 (SPATA1)
Synonyms Sperm-specific protein SP-2
Gene Name SPATA1
Related Disease
Chronic hepatitis B virus infection ( )
UniProt ID
SPAT1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15743
Sequence
MKKDKKRNKIPIDNYPIQTLVNMSLNPSRPSSSELVELHVFYVPEGSWNYKLNTISTEVV
NKFISAGFLRVSPQLTLRALRERLGEFLGEDAIAEKFLFLKCIGNNLAVVKEKQESELKL
KSFAPPYALQPELYLLPVMDHLGNVYSPSTVILDERQTNNGVNEADGTIHRPISVTLFKE
ELGRDPSLLENTLKELPNKNQEEAGGKATAEKSQIAKNQIGNSELPGSLEDSNNDCFGTK
KSQCLWENEDDTAISRRQDNQTAEKEYITLPDHPSLPCQPVLSSGITDISLLQTEREKII
KQMKQVKEERRYLERNREELVKTVEKLFEQSKLKRYHAYNGWKKKYLETKKVTASMEEVL
TKLREDLELYYKKLLMQLEAREIKMRPKNLANITDSKNYLIIQITEVQHAIDQLKRKLDT
DKMKLIVEVKMRKQAVSDLRTLKTELAQKKKIIHLYNLN

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Chronic hepatitis B virus infection DISHL4NT moderate Genetic Variation [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of Spermatogenesis-associated protein 1 (SPATA1). [2]
Urethane DM7NSI0 Phase 4 Urethane increases the expression of Spermatogenesis-associated protein 1 (SPATA1). [3]
Maleic Acid DM4L0R7 Investigative Maleic Acid increases the expression of Spermatogenesis-associated protein 1 (SPATA1). [4]
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References

1 Stimulation of human lymphocyte proliferation and CD40 antigen expression by phosphorothioate oligonucleotides complementary to hepatitis B virus genome.J Viral Hepat. 1996 Jul;3(4):167-72. doi: 10.1111/j.1365-2893.1996.tb00091.x.
2 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
3 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
4 Profiling transcriptomes of human SH-SY5Y neuroblastoma cells exposed to maleic acid. PeerJ. 2017 Apr 5;5:e3175.