Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTIESHK4)

DOT Name Poly polymerase 1 (PARP1)
Synonyms PARP-1; EC 2.4.2.30; NAD(+) ADP-ribosyltransferase 1; ADPRT-1; Poly synthase 1; Protein ADP-ribosyltransferase PARP1; EC 2.4.2.-
Gene Name PARP1
UniProt ID
PARP1_ARATH
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
1V9X
EC Number
2.4.2.-; 2.4.2.30
Pfam ID
PF00533 ; PF21728 ; PF08063 ; PF00644 ; PF02877 ; PF05406 ; PF00645
Sequence
MASPHKPWRAEYAKSSRSSCKTCKSVINKENFRLGKLVQSTHFDGIMPMWNHASCILKKT
KQIKSVDDVEGIESLRWEDQQKIRKYVESGAGSNTSTSTGTSTSSTANNAKLEYGIEVSQ
TSRAGCRKCSEKILKGEVRIFSKPEGPGNKGLMWHHAKCFLEMSSSTELESLSGWRSIPD
SDQEALLPLVKKALPAAKTETAEARQTNSRAGTKRKNDSVDNEKSKLAKSSFDMSTSGAL
QPCSKEKEMEAQTKELWDLKDDLKKYVTSAELREMLEVNEQSTRGSELDLRDKCADGMMF
GPLALCPMCSGHLSFSGGLYRCHGYISEWSKCSHSTLDPDRIKGKWKIPDETENQFLLKW
NKSQKSVKPKRILRPVLSGETSQGQGSKDATDSSRSERLADLKVSIAGNTKERQPWKKRI
EEAGAEFHANVKKGTSCLVVCGLTDIRDAEMRKARRMKVAIVREDYLVDCFKKQRKLPFD
KYKIEDTSESLVTVKVKGRSAVHEASGLQEHCHILEDGNSIYNTTLSMSDLSTGINSYYI
LQIIQEDKGSDCYVFRKWGRVGNEKIGGNKVEEMSKSDAVHEFKRLFLEKTGNTWESWEQ
KTNFQKQPGKFLPLDIDYGVNKQVAKKEPFQTSSNLAPSLIELMKMLFDVETYRSAMMEF
EINMSEMPLGKLSKHNIQKGFEALTEIQRLLTESDPQPTMKESLLVDASNRFFTMIPSIH
PHIIRDEDDFKSKVKMLEALQDIEIASRIVGFDVDSTESLDDKYKKLHCDISPLPHDSED
YRLIEKYLNTTHAPTHTEWSLELEEVFALEREGEFDKYAPHREKLGNKMLLWHGSRLTNF
VGILNQGLRIAPPEAPATGYMFGKGIYFADLVSKSAQYCYTCKKNPVGLMLLSEVALGEI
HELTKAKYMDKPPRGKHSTKGLGKKVPQDSEFAKWRGDVTVPCGKPVSSKVKASELMYNE
YIVYDTAQVKLQFLLKVRFKHKR
Function
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 3 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Dexamethasone DMMWZET Approved Poly polymerase 1 (PARP1) increases the Apoptosis ADR of Dexamethasone. [1]
Paclitaxel DMLB81S Approved Poly polymerase 1 (PARP1) increases the Mitochondrial toxicity ADR of Paclitaxel. [1]
Uracil mustard DMHL7OB Approved Poly polymerase 1 (PARP1) increases the Cell death ADR of Uracil mustard. [1]
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References

1 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.