Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTMAOLX2)

DOT Name F-box only protein 47 (FBXO47)
Gene Name FBXO47
Related Disease
Multiple system atrophy ( )
Neoplasm ( )
Papillary renal cell carcinoma ( )
UniProt ID
FBX47_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00646
Sequence
MASRINTNFTLIPNQKLRRSNRQTSCYSKTLGSGFQPISTFGNFKALPLEIFQIILKYLS
VKDISMLSMVSKTVSQHIINYISTSSGSKRLLLQDFHNLELPDRRQDSAILEHYRSLGLL
FKRCTLLLPTKERLKYIHKILTEVSCFKFNGCAAPMQCLGLTCYGMFLQTLTAGWDELEC
HRVYNFLCELTNLCRKIQMAVCSKPGSAQKLELRIRLFCRNVLLDHWTHRSDSAFWLTRI
LKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEPTDEFSLKGLADAIKLLYDASTKEW
TADDVISLVDELSVVPREWLLENNARLLMLSGNNICFSFMASKAVNGRTIELARLVVFLA
LVCEKELYCMDWTVKMMQKVCKVFSTPVERKNFLQNVANAFACVIMEMLQSIMSGDRDED
DRSFLNLFHLVHAQANFHKEVLYLTMNTPLST
Function Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Tissue Specificity Widely expressed, with highest levels in kidney, liver and pancreas. Down-regulated in tumors.

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Multiple system atrophy DISASEYE Strong Genetic Variation [1]
Neoplasm DISZKGEW Strong Altered Expression [2]
Papillary renal cell carcinoma DIS25HBV Strong Biomarker [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of F-box only protein 47 (FBXO47). [3]
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References

1 A genome-wide association study in multiple system atrophy.Neurology. 2016 Oct 11;87(15):1591-1598. doi: 10.1212/WNL.0000000000003221. Epub 2016 Sep 14.
2 Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma.Genes Chromosomes Cancer. 2005 May;43(1):83-94. doi: 10.1002/gcc.20170.
3 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.