Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTON4K9S)

• DOT Name: Sialic acid-binding Ig-like lectin 15 (SIGLEC15)
• Synonyms: Siglec-15; CD33 antigen-like 3
• Gene Name: SIGLEC15
• UniProt ID: SIG15_HUMAN
• PDB ID: 7ZOZ
• Pfam ID: PF07686
• Sequence:
  MEKSIWLLACLAWVLPTGSFVRTKIDTTENLLNTEVHSSPAQRWSMQVPPEVSAEAGDAA
  VLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSELCQTALSLHGRFRLLGNP
  RRNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGVRLHVTAAPRIVNISVLPSPA
  HAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGHGHLVTAELPALTHDGRYTCTAA
  NSLGRSEASVYLFRFHGASGASTVALLLGALGFKALLLLGVLAARAARRRPEHLDTPDTP
  PRSQAQESNYENLSQMNPRSPPATMCSP
• Function: Binds sialylated glycoproteins.
• Tissue Specificity: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.
• Reactome Pathway: DAP12 interactions (R-HSA-2172127)

Molecular Interaction Atlas (MIA) of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
PD-0325901	DM27D4J	Phase 2	PD-0325901 decreases the expression of Sialic acid-binding Ig-like lectin 15 (SIGLEC15).	[1]
(+)-JQ1	DM1CZSJ	Phase 1	(+)-JQ1 decreases the expression of Sialic acid-binding Ig-like lectin 15 (SIGLEC15).	[3]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Sialic acid-binding Ig-like lectin 15 (SIGLEC15).	[2]

References

• [1] PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
• [2] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [3] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.