Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTPHOGIE)

DOT Name	Lens epithelial cell protein LEP503 (LENEP)
Gene Name	LENEP
UniProt ID	LENEP_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF15221
Sequence	MQPRTQPLAQTLPFFLGGAPRDTGLRVPVIKMGTGWEGFQRTLKEVAYILLCCWCIKELL D
Function	May play a role in lens epithelial cell differentiation.
Tissue Specificity	Restricted to lens epithelial cells.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Leflunomide	DMR8ONJ	Phase 1 Trial	Leflunomide decreases the expression of Lens epithelial cell protein LEP503 (LENEP).	[1]
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References

1	Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.