Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTQSXM9Z)

DOT Name	Calcitonin gene-related peptide 1 (CALCA)
Synonyms	Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I
Gene Name	CALCA
UniProt ID	CALCA_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
PDB ID	6E3Y; 7KNU
Pfam ID	PF00214
Sequence	MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQ MKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFG RRRRDLQA
Function	CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
Reactome Pathway	Calcitonin-like ligand receptors (R-HSA-419812 ) G alpha (s) signalling events (R-HSA-418555 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Sumatriptan	DMVYXR8	Approved	Calcitonin gene-related peptide 1 (CALCA) increases the Cytogenetic abnormality ADR of Sumatriptan.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.