Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTS88GMA)

DOT Name	Apolipoprotein B (APOB)
Gene Name	APOB
UniProt ID	APOB_CHICK
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF12491
Sequence	IPGLSEKYTGEELYLMTTEKAAKTADICLSKLQEYFDALIAAISELEVRVPASETILRGR NVLDQIKEMLKHLQEKIRQTFVTLQEADFAGKLNRLKQVVQKTFQKAGNMVRSLQSKNFE DIKVQMQQLYKDAMASDYAHKLRSLAENVKKYISQIKNFSQKTLQKLSENLQQLVLYIKA LREEYFDPTTLGWSVKYYEVEDKVLGLLKNLMDTLVIWYNEYAKDLSDLVTRLTDQVREL VENYRQEYYDLITDVEGKGRQKVMELSSAAQEKIRYWSAVAKRKINEHNRQVKAKLQEIY GQLSDSQEKLINVAKMLIDLTVEKYSTFMKYIFELLRWFEQATADSIKPYIAVREGELRI DVPFDWEYINQMPQKSREALRNKVELTRALIQQGVEQGTRKWEEMQAFIDEQLATEQLSF QQIVENIQKRMKT
Function	Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
PMID27977313-Compound-29	DMIF7KG	Patented	Apolipoprotein B (APOB) increases the Lipids abnormal ADR of PMID27977313-Compound-29.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.