Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTTLKELW)

DOT Name LysM and putative peptidoglycan-binding domain-containing protein 1 (LYSMD1)
Gene Name LYSMD1
UniProt ID
LYSM1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
2DJP
Pfam ID
PF01476
Sequence
MASPSRQPPPGGSGLLQGSRARSYGSLVQSACSPVRERRLEHQLEPGDTLAGLALKYGVT
MEQIKRANRLYTNDSIFLKKTLYIPILTEPRDLFNGLDSEEEKDGEEKVHPSNSEVWPHS
TERKKQETGAGRANGEVLPTPGQETPTPIHDLSASDFLKKLDSQISLSKKAAAQKLKKGE
NGVPGEDAGLHLSSPWMQQRAVLGPVPLTRTSRTRTLRDQEDEIFKL

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Cannabidiol DM0659E Approved Cannabidiol decreases the expression of LysM and putative peptidoglycan-binding domain-containing protein 1 (LYSMD1). [1]
Urethane DM7NSI0 Phase 4 Urethane affects the expression of LysM and putative peptidoglycan-binding domain-containing protein 1 (LYSMD1). [2]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of LysM and putative peptidoglycan-binding domain-containing protein 1 (LYSMD1). [3]
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References

1 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
2 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
3 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.