Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTVDLQ4J)

DOT Name Keratin-associated protein 5-1 (KRTAP5-1)
Synonyms Keratin, cuticle, ultrahigh sulphur 1-like; Keratin-associated protein 5.1; Ultrahigh sulfur keratin-associated protein 5.1
Gene Name KRTAP5-1
Related Disease
Epidermolytic ichthyosis ( )
UniProt ID
KRA51_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGCCGCSGGCGSSCGGCGSGCGGCGSGCGGCGSGCGGSGSSCCVPVCCCKPVCCRVPTCS
CSSCGKGGCGSSGGSKGGCGSCGGCKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCG
SGCGGCGSSCCVPVCCCKPMCCCVPACSCSSCGKGGCGSCGCSKGACGSCGGSKGGCGSC
GGCKGGCGSCGGSKGGCGSGCGGCGSGCGVPVCCCSCSSCGSCAGSKGGCGSSCSQCSCC
KPCCCSSGCGSSCCQSSCCKPCCSQSSCCVPVCCQCKI
Function
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Tissue Specificity Expressed in hair root but not in skin. Expressed also in lung, pancreas, ovary, testis.
Reactome Pathway
Keratinization (R-HSA-6805567 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Epidermolytic ichthyosis DISJPEP3 Strong Genetic Variation [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Keratin-associated protein 5-1 (KRTAP5-1). [2]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 decreases the expression of Keratin-associated protein 5-1 (KRTAP5-1). [3]
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References

1 Keratin 1 and keratin 10 mutations causing epidermolytic hyperkeratosis in Chinese patients.J Dermatol Sci. 2002 Sep;29(3):195-200. doi: 10.1016/s0923-1811(02)00040-3.
2 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
3 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.