Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTVJTEXT)

DOT Name	Putative PRAME family member 13 (PRAMEF13)
Gene Name	PRAMEF13
Related Disease	Sjogren syndrome ( )
UniProt ID	PRA13_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSIQAPPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFMEAFRRRHFQTLTVMVQAWP FTCLPLGSLMKTLHLETLKALLEGLHMLLTQKDRPRRRKLQVLDLRDVDENFWARWPGAW ALSCFPETMSKRQTAEDRPRMGEHQPLKVFIDICLKEIPQDECLRYLFQWVYQRRGLVHL CCSKLVNYLTPIKHLRKSLKIIYLNSIQELEIHNMSWPRLIRKLRCYLKEMKTLGKLVFS RCHHSTSDNELEGRLVTKFSSVFLGLEHLQLLKIKLITFFSGHLEQLIRCLQNPLENLEL TYGYLLEEDVKCLSQYPSLGYLKHLNLSYVLLFRISLEPLGALLEKIAASLETLILEGCQ IHYSQLSAILPGLSRCSQLTTFYFGRNCMSMGALKDLLRHTSGLSKLSLETYPAPEESLN SLVRVNWEIFTPLRAELMCTLREVRQPKRIFIGPTPCPSCGSSLSEELELHLCC

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance		REF
Sjogren syndrome	DISUBX7H	Strong	Genetic Variation	[1]
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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Arsenic trioxide	DM61TA4	Approved	Arsenic trioxide increases the expression of Putative PRAME family member 13 (PRAMEF13).	[2]
Vitamin C	DMXJ7O8	Approved	Vitamin C increases the expression of Putative PRAME family member 13 (PRAMEF13).	[2]
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References

1	Variants at potential loci associated with Sjogren's syndrome in Koreans: A genetic association study.Clin Immunol. 2019 Oct;207:79-86. doi: 10.1016/j.clim.2019.07.010. Epub 2019 Jul 23.
2	Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.