Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTW8VKBZ)

DOT Name	Low-density lipoprotein receptor class A domain-containing protein 2 (LDLRAD2)
Gene Name	LDLRAD2
Related Disease	Gastric cancer ( ) Stomach cancer ( )
UniProt ID	LRAD2_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF00057
Sequence	MEACCLLQLPQRLLLLGAAALTATALETADLAELCGQTWQGDGLLLRSHAASRRFYFVAP DTDCGLWVQAAAPGDRIRFQFRFFLVYSLTPAPPALNTSSPAPADPCAPGSYLQFYEGPP GAPRPLGSPLCGLNIPVPVASSGPFLGLRLVTRGRQPRVDFVGEVTSFRLGPCGAYFRCQ NGRCIPSSLVCDPWGMDNCGDGSDQGSWSPADCRGPSPVPSQTGSTDAHTSRSLTPSPAL GSAGSLWIAAERSSPAGRDPTRQDAALEGSTE

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance
Gastric cancer	DISXGOUK	Definitive	Biomarker	[1]
Stomach cancer	DISKIJSX	Definitive	Biomarker	[1]
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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene affects the expression of Low-density lipoprotein receptor class A domain-containing protein 2 (LDLRAD2).	[2]
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References

1	LDLRAD2 overexpression predicts poor prognosis and promotes metastasis by activating Wnt/-catenin/EMT signaling cascade in gastric cancer.Aging (Albany NY). 2019 Oct 24;11(20):8951-8968. doi: 10.18632/aging.102359. Epub 2019 Oct 24.
2	High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity. Nucleic Acids Res. 2015 Mar 11;43(5):2525-34. doi: 10.1093/nar/gkv115. Epub 2015 Feb 17.