Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTWL4LDO)

DOT Name Dynein regulatory complex subunit 5 (TCTE1)
Synonyms T-complex-associated testis-expressed protein 1; Tcte-1
Gene Name TCTE1
Related Disease
Spinocerebellar ataxia type 1 ( )
Cleidocranial dysplasia 1 ( )
UniProt ID
DRC5_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
8J07
Pfam ID
PF13516
Sequence
MQDTVTTSALLDPSHSSVSTQDNSSTGGHTSSTSPQLSKPSITPVPAKSRNPHPRANIRR
MRRIIAEDPEWSLAIVPLLTELCIQHIIRNFQKNPILKQMLPEHQQKVLNHLSPDLPLAV
TANLIDSENYWLRCCMHRWPVCHVAHHGGSWKRMFFERHLENLLKHFIPGTTDPAVILDL
LPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQLGDLVAGLSHL
EELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIII
RSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAH
NTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTL
TSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREAARQR
ALNPSHFMSTITANGPENSVG
Function
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Spinocerebellar ataxia type 1 DISF7BO2 Definitive Genetic Variation [1]
Cleidocranial dysplasia 1 DIS2OHLA Strong Genetic Variation [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Dynein regulatory complex subunit 5 (TCTE1). [3]
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References

1 The gene for autosomal dominant spinocerebellar ataxia (SCA1) maps telomeric to the HLA complex and is closely linked to the D6S89 locus in three large kindreds.Am J Hum Genet. 1991 Jul;49(1):23-30.
2 Genetic mapping of cleidocranial dysplasia and evidence of a microdeletion in one family.Hum Mol Genet. 1995 Jan;4(1):71-5. doi: 10.1093/hmg/4.1.71.
3 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.