Details of the Drug Combination

General Information of Drug Combination (ID: DC0OA7K)

Drug Combination Name
Phensuximide AS-1949490
Indication
Disease Entry Status REF
Chronic myelogenous leukemia Investigative [1]
Component Drugs Phensuximide   DMFGLXB AS-1949490   DMZ1OO0
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: KBM-7
Zero Interaction Potency (ZIP) Score: 0.08
Bliss Independence Score: 0.08
Loewe Additivity Score: 12.66
LHighest Single Agent (HSA) Score: 12.66

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Phensuximide FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7612).
4 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.