Details of the Drug Combination

General Information of Drug Combination (ID: DC13147)

• Drug Combination Name: BIO-300 + Bleomycin
• Indication: Adenocarcinoma; Status: Investigative [1]
• Component Drugs:
  BIO-300 (DMJ7NVI): N.A.
  Bleomycin (DMNER5S): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: HCT-15
  Zero Interaction Potency (ZIP) Score: 5.58
  Bliss Independence Score: 7.32
  Loewe Additivity Score: 6.74
  LHighest Single Agent (HSA) Score: 11.32

Molecular Interaction Atlas of This Drug Combination

Indication(s) of BIO-300

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]
Rheumatoid arthritis	FA20	Phase 1	[3]

Indication(s) of Bleomycin

Disease Entry	ICD 11	Status	REF
Cervical cancer	2C77.0	Approved	[4]
Head and neck cancer	2D42	Approved	[4]
Hodgkin lymphoma	2B30	Approved	[5]
Penile cancer	N.A.	Approved	[4]
Testicular germ cell tumor	N.A.	Approved	[4]
Classic Hodgkin lymphoma	N.A.	Investigative	[4]
Follicular lymphoma	2A80	Investigative	[4]

Bleomycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Breaker	[10]

Bleomycin Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Bleomycin hydrolase (BLMH)	DECH1VP	BLMH_HUMAN	Metabolism	[11]

Bleomycin Interacts with 41 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Bleomycin hydrolase (BLMH)	OT2QPWQJ	BLMH_HUMAN	Affects Response To Substance	[12]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases Expression	[13]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Increases Expression	[13]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[13]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[14]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Increases Expression	[14]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[14]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Increases Expression	[14]
Mucin-5AC (MUC5AC)	OTJV8O04	MUC5A_HUMAN	Increases Expression	[14]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Increases Expression	[14]
Transmembrane protein 250 (TMEM250)	OTLJ4G5G	TM250_HUMAN	Increases Expression	[6]
Suppressor of cytokine signaling 1 (SOCS1)	OTWA9KFU	SOCS1_HUMAN	Decreases Expression	[15]
Serine/threonine-protein kinase Chk2 (CHEK2)	OT8ZPCNS	CHK2_HUMAN	Increases Phosphorylation	[16]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Increases Expression	[7]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[17]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[7]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Increases Expression	[7]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[18]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[7]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[19]
Cathepsin S (CTSS)	OT3PXIPM	CATS_HUMAN	Increases Expression	[20]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[21]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Decreases Expression	[6]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Increases Expression	[7]
Unconventional myosin-Ie (MYO1E)	OTM9YSIZ	MYO1E_HUMAN	Decreases Expression	[6]
Transcription intermediary factor 1-beta (TRIM28)	OTE38OBF	TIF1B_HUMAN	Increases Phosphorylation	[16]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Increases Phosphorylation	[16]
Structural maintenance of chromosomes protein 1A (SMC1A)	OT9ZMRK9	SMC1A_HUMAN	Increases Phosphorylation	[16]
7SK snRNA methylphosphate capping enzyme (MEPCE)	OTRBQEYP	MEPCE_HUMAN	Increases Expression	[6]
Transmembrane protein 87A (TMEM87A)	OT8ATDVX	TM87A_HUMAN	Increases Expression	[6]
Terminal nucleotidyltransferase 4B (TENT4B)	OTUF6FWW	PAPD5_HUMAN	Decreases Expression	[6]
Lipase member H (LIPH)	OTRGYLKL	LIPH_HUMAN	Decreases Expression	[6]
Abasic site processing protein HMCES (HMCES)	OTVRDL6U	HMCES_HUMAN	Decreases Expression	[6]
Small integral membrane protein 14 (SMIM14)	OT47IF19	SIM14_HUMAN	Decreases Expression	[6]
Kelch-like protein 42 (KLHL42)	OTK6WARI	KLH42_HUMAN	Increases Expression	[6]
Inactive cell surface hyaluronidase CEMIP2 (CEMIP2)	OT9I1XUO	CEIP2_HUMAN	Decreases Expression	[6]
ERBB receptor feedback inhibitor 1 (ERRFI1)	OT7VZ2IZ	ERRFI_HUMAN	Decreases Expression	[6]
Transmembrane and coiled-coil domain protein 3 (TMCC3)	OTAIQ6V6	TMCC3_HUMAN	Decreases Expression	[6]
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)	OT27CCUF	SIAT9_HUMAN	Decreases Expression	[6]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Decreases Response To Substance	[22]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Affects Response To Substance	[23]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCO50A4	HL-60(TB)	Investigative	[24]
Adult T acute lymphoblastic leukemia	DCMV8BE	MOLT-4	Investigative	[24]
Anaplastic large cell lymphoma	DCRJHOG	SR	Investigative	[24]
Astrocytoma	DC304HQ	U251	Investigative	[24]
Astrocytoma	DC8ZIGX	SNB-19	Investigative	[24]
Childhood T acute lymphoblastic leukemia	DCZ6DFM	CCRF-CEM	Investigative	[24]
Chronic myelogenous leukemia	DC2YPZ8	K-562	Investigative	[24]
Clear cell renal cell carcinoma	DCNHC16	786-0	Investigative	[24]
Clear cell renal cell carcinoma	DC6NHMT	A498	Investigative	[24]
Clear cell renal cell carcinoma	DC354OV	TK-10	Investigative	[24]
Clear cell renal cell carcinoma	DCMFEJO	CAKI-1	Investigative	[24]
Glioblastoma	DCQ8K11	SNB-75	Investigative	[24]
Glioma	DCCEQYH	SF-268	Investigative	[24]
Glioma	DCGKGRE	SF-539	Investigative	[24]
Glioma	DCWDKRP	SF-295	Investigative	[24]
Papillary renal cell carcinoma	DCYSK81	ACHN	Investigative	[24]
Renal cell carcinoma	DCUUJ47	SN12C	Investigative	[24]
Breast adenocarcinoma	DCEC6CR	MDA-MB-468	Investigative	[25]
Colon adenocarcinoma	DC2VSQR	COLO 205	Investigative	[25]
Colon carcinoma	DC3D7EE	KM12	Investigative	[25]
Invasive ductal carcinoma	DC01CJE	BT-549	Investigative	[25]
Invasive ductal carcinoma	DCXWR0K	HS 578T	Investigative	[25]
Adenocarcinoma	DC2JRFI	DU-145	Investigative	[1]
Adenocarcinoma	DC85IU0	OVCAR3	Investigative	[1]
Adenocarcinoma	DC9OOHQ	A549	Investigative	[1]
Adenocarcinoma	DCSDYQA	HCT116	Investigative	[1]
Adenocarcinoma	DCSFYUI	SW-620	Investigative	[1]
Adenocarcinoma	DCTO54C	HCC-2998	Investigative	[1]
Amelanotic melanoma	DC0OCST	M14	Investigative	[1]
Cutaneous melanoma	DCWPQXH	SK-MEL-28	Investigative	[1]
Cutaneous melanoma	DC6NCGE	SK-MEL-5	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCRZPG9	OVCAR-5	Investigative	[1]
High grade ovarian serous adenocarcinoma	DC2JP98	OVCAR-8	Investigative	[1]
Large cell lung carcinoma	DCS8V89	NCI-H460	Investigative	[1]
Lung adenocarcinoma	DCMXPAB	HOP-62	Investigative	[1]
Lung adenocarcinoma	DCZSDMS	EKVX	Investigative	[1]
Malignant melanoma	DC4VNHN	UACC62	Investigative	[1]
Malignant melanoma	DCJNYPK	LOX IMVI	Investigative	[1]
Melanoma	DC01PE4	UACC-257	Investigative	[1]
Melanoma	DCWAAN5	SK-MEL-2	Investigative	[1]
Melanoma	DCFOYZN	MALME-3M	Investigative	[1]
Mixed endometrioid and clear cell carcinoma	DC43L41	IGROV1	Investigative	[1]
Ovarian serous cystadenocarcinoma	DCPTKQN	SK-OV-3	Investigative	[1]

References

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