Details of the Drug Combination

General Information of Drug Combination (ID: DC1IM8K)

Drug Combination Name
Venglustat ONC201
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs Venglustat   DMLPEZS ONC201   DMM5SCF
N.A. N.A.
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DIPG25
Zero Interaction Potency (ZIP) Score: 42.96
Bliss Independence Score: 43.967
Loewe Additivity Score: 0.597
LHighest Single Agent (HSA) Score: 2.641

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Venglustat
Disease Entry ICD 11 Status REF
Fabry disease 5C56.01 Phase 2 [2]
Parkinson disease 8A00.0 Phase 2 [3]
Gaucher disease 5C56.0Y Phase 1 [4]
Venglustat Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Ceramide glucosyltransferase (UGCG) TTPHEX3 CEGT_HUMAN Inhibitor [3]
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Indication(s) of ONC201
Disease Entry ICD 11 Status REF
Endometrial cancer 2C76 Phase 2 [5]
Glioma 2A00.0 Phase 2 [5]
Multiple myeloma 2A83 Phase 2 [5]
Neuroendocrine cancer 2B72.1 Phase 2 [5]
Recurring respiratory infection CA07-CA45 Phase 2 [5]
leukaemia 2A60-2B33 Phase 1/2 [5]
Lymphoma 2A80-2A86 Phase 1/2 [5]
Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
ONC201 Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Dopamine D3 receptor (D3R) TT4C8EA DRD3_HUMAN Antagonist [5]
Dopamine receptor (DR) TTWFZ1N NOUNIPROTAC Antagonist [3]
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Antagonist [5]
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References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036945)
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)