Details of the Drug Combination

General Information of Drug Combination (ID: DC35V15)

Drug Combination Name
Vinflunine Pentostatin
Indication
Disease Entry Status REF
Malignant melanoma Investigative [1]
Component Drugs Vinflunine   DMTJAEP Pentostatin   DM0HXDS
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: UACC62
Zero Interaction Potency (ZIP) Score: 2.57
Bliss Independence Score: 3.77
Loewe Additivity Score: 0.73
LHighest Single Agent (HSA) Score: 0.73

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Vinflunine
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Approved [2]
Indication(s) of Pentostatin
Disease Entry ICD 11 Status REF
Acute graft versus host disease 4B24.0 Approved [3]
Hairy cell leukaemia 2A82.2 Approved [4]
Leukemia N.A. Approved [3]
Pentostatin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adenosine deaminase (ADA) TTLP57V ADA_HUMAN Inhibitor [5]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Anaplastic large cell lymphoma DCSDWSD SR Investigative [6]
Clear cell renal cell carcinoma DC63EUD CAKI-1 Investigative [6]
Plasma cell myeloma DCLB66M RPMI-8226 Investigative [6]
Renal cell carcinoma DCVUWRB UO-31 Investigative [6]
High grade ovarian serous adenocarcinoma DCEA5WP OVCAR-8 Investigative [1]
High grade ovarian serous adenocarcinoma DCCSMQ8 NCI\\/ADR-RES Investigative [1]
Malignant melanoma DCU4WVF LOX IMVI Investigative [1]
Minimally invasive lung adenocarcinoma DCFTKAJ NCI-H322M Investigative [1]
Ovarian serous cystadenocarcinoma DC6NQGY SK-OV-3 Investigative [1]
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⏷ Show the Full List of 9 DrugCom(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Pentostatin FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4805).
5 Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
6 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.