Details of the Drug Combination

General Information of Drug Combination (ID: DC3AKDF)

Drug Combination Name
MK-1775 SCH-900776
Indication
Disease Entry Status REF
Colon carcinoma Investigative [1]
Component Drugs MK-1775   DM3WDZ5 SCH-900776   DM67EMK
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: RKO
Zero Interaction Potency (ZIP) Score: 3.09
Bliss Independence Score: 2.82
Loewe Additivity Score: 4.21
LHighest Single Agent (HSA) Score: 8.66

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of MK-1775
Disease Entry ICD 11 Status REF
Ovarian cancer 2C73 Phase 2 [2]
Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
MK-1775 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Wee1-like protein kinase (WEE1) TTJFOAL WEE1_HUMAN Inhibitor [6]
------------------------------------------------------------------------------------
MK-1775 Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Phosphorylation [5]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Response To Substance [5]
------------------------------------------------------------------------------------
Indication(s) of SCH-900776
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [4]
SCH-900776 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Checkpoint kinase-1 (CHK1) TTTU902 CHK1_HUMAN Inhibitor [7]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma DC48JJX CAOV3 Investigative [8]
Adenocarcinoma DC230YQ OVCAR3 Investigative [8]
Adenocarcinoma DCG16WG A427 Investigative [8]
Adenocarcinoma DC7VGCL NCIH2122 Investigative [8]
Adenocarcinoma DCYVKW7 NCIH520 Investigative [8]
Adenocarcinoma DCTWTOL COLO320DM Investigative [8]
Adenocarcinoma DCIA82B DLD1 Investigative [8]
Adenocarcinoma DCEWOL1 HCT116 Investigative [8]
Adenocarcinoma DCSTMED HT29 Investigative [8]
Amelanotic melanoma DCA7ZQN A2058 Investigative [8]
Germ cell tumour DCHVP8T PA1 Investigative [8]
Large cell lung carcinoma DC8HG4N NCI-H460 Investigative [8]
Malignant melanoma DCD281V A375 Investigative [8]
Malignant melanoma DC3ECQB HT144 Investigative [8]
Malignant melanoma DC4DUCX RPMI7951 Investigative [8]
Malignant melanoma DC34STB SKMEL30 Investigative [8]
Mesothelioma DC7RI9T MSTO Investigative [8]
Ovarian endometrioid adenocarcinoma DCL0ELV A2780 Investigative [8]
Prostate carcinoma DCXSBYW VCAP Investigative [8]
Breast carcinoma DCWS3AK ZR751 Investigative [1]
Breast carcinoma DC4F2BU OCUBM Investigative [1]
Carcinoma DC06G64 OV90 Investigative [1]
Invasive ductal carcinoma DC89Z74 T-47D Investigative [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 23 DrugCom(s)

References

1 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7702).
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7943).
5 Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res. 2014 Aug 15;20(16):4274-88. doi: 10.1158/1078-0432.CCR-13-2858.
6 A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8.
7 Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602.
8 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.