Details of the Drug Combination

General Information of Drug Combination (ID: DC3GGAO)

Drug Combination Name
TEM Triapine
Indication
Disease Entry Status REF
Adenocarcinoma Investigative [1]
Component Drugs TEM   DMLNFWU Triapine   DM7XZY5
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: HCC-2998
Zero Interaction Potency (ZIP) Score: 4.93
Bliss Independence Score: 7.92
Loewe Additivity Score: 4.39
LHighest Single Agent (HSA) Score: 0.33

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of TEM
Disease Entry ICD 11 Status REF
Postherpetic neuralgia 1E91.5 Phase 2 [2]
Indication(s) of Triapine
Disease Entry ICD 11 Status REF
Nerve injury ND56.4 Phase 2 [3]
Triapine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Ribonucleoside-diphosphate reductase M2 (RRM2) TTBWDI0 RIR2_HUMAN Modulator [3]
------------------------------------------------------------------------------------
Triapine Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [5]
Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) OTLB2WEU PRDX3_HUMAN Increases Oxidation [4]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Astrocytoma DC66VY4 U251 Investigative [6]
Clear cell renal cell carcinoma DCCX209 A498 Investigative [6]
Glioblastoma DC36C95 SNB-75 Investigative [6]
Colon adenocarcinoma DCBRF1B COLO 205 Investigative [7]
Invasive ductal carcinoma DCWB9VU HS 578T Investigative [7]
Invasive ductal carcinoma DCETXQ5 T-47D Investigative [7]
Adenocarcinoma DCH5LY8 OVCAR3 Investigative [1]
Adenocarcinoma DCTI9PD A549 Investigative [1]
Adenocarcinoma DCH36GV HCT116 Investigative [1]
Adenocarcinoma DCXH4UQ HCT-15 Investigative [1]
Melanoma DCO7ICO MALME-3M Investigative [1]
Minimally invasive lung adenocarcinoma DCCNG2S NCI-H322M Investigative [1]
Prostate carcinoma DC9N4RH PC-3 Investigative [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 13 DrugCom(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3 PAN-811 inhibits oxidative stress-induced cell death of human Alzheimer's disease-derived and age-matched olfactory neuroepithelial cells via suppression of intracellular reactive oxygen species. J Alzheimers Dis. 2009;17(3):611-9.
4 The iron-chelating drug triapine causes pronounced mitochondrial thiol redox stress. Toxicol Lett. 2011 Mar 5;201(2):130-6. doi: 10.1016/j.toxlet.2010.12.017. Epub 2010 Dec 31.
5 Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes. Biochem Pharmacol. 2014 Oct 1;91(3):312-22. doi: 10.1016/j.bcp.2014.08.006. Epub 2014 Aug 15.
6 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
7 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.