General Information of Drug Combination (ID: DC52MGE)

Drug Combination Name
DFN-15 Hepzato
Indication
Disease Entry Status REF
Adenocarcinoma Investigative [1]
Component Drugs DFN-15   DM3BF9B Hepzato   DM2AZPP
N.A. N.A.
High-throughput Screening Result Testing Cell Line: HT29
Zero Interaction Potency (ZIP) Score: 7.28
Bliss Independence Score: 9.75
Loewe Additivity Score: 4.54
LHighest Single Agent (HSA) Score: 1.51

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Carcinoma DCOM1GF RXF 393 Investigative [4]
Adenocarcinoma DC6352A OVCAR3 Investigative [1]
Lung adenocarcinoma DCAAE55 MDA-MB-231 Investigative [1]
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References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 ClinicalTrials.gov (NCT05022901) An Open-Label Expanded Access Study of the Melphalan/Hepatic Delivery System (HDS) in Patients With Hepatic Dominant Ocular Melanoma. U.S.National Institutes of Health.
4 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.