Details of the Drug Combination

General Information of Drug Combination (ID: DC7FJ8J)

Drug Combination Name
Remimazolam Remifentanil
Indication
Disease Entry Status REF
Anesthesia Phase 1 [1]
Component Drugs Remimazolam   DMLVSYX Remifentanil   DMZTXCH
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Remimazolam
Disease Entry ICD 11 Status REF
Procedural sedation JB0C.3 Approved [2]
Anaesthesia 9A78.6 Phase 3 [3]
Remimazolam Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
GABA(A) receptor gamma-3 (GABRG3) TTEX6LM GBRG3_HUMAN Agonist [2]
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Indication(s) of Remifentanil
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [4]
Remifentanil Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Opioid receptor mu (MOP) TTKWM86 OPRM_HUMAN Agonist [5]
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References

1 ClinicalTrials.gov (NCT04670471) Assessment of the Pharmacodynamic and Pharmacokinetic Interaction of Remimazolam and Remifentanil
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8442).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7292).
5 The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevent... Pain. 2009 Jan;141(1-2):88-96.