Details of the Drug Combination

General Information of Drug Combination (ID: DC84HKW)

Drug Combination Name
Desflurane Remifentanil
Indication
Disease Entry Status REF
Anesthesia Phase 4 [1]
Component Drugs Desflurane   DM2TO9R Remifentanil   DMZTXCH
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Desflurane
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [2]
Desflurane Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Antagonist [4]
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Indication(s) of Remifentanil
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [3]
Remifentanil Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Opioid receptor mu (MOP) TTKWM86 OPRM_HUMAN Agonist [5]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Cholecystitis DCVDVMF N. A. Phase 1 [6]
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References

1 ClinicalTrials.gov (NCT02379715) Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7156).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7292).
4 Modulation of NMDA receptor function by ketamine and magnesium. Part II: interactions with volatile anesthetics. Anesth Analg. 2001 May;92(5):1182-91.
5 The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevent... Pain. 2009 Jan;141(1-2):88-96.
6 ClinicalTrials.gov (NCT01937104) ONSD According to the Position During Laparoscopy