Details of the Drug Combination

General Information of Drug Combination (ID: DC8HATX)

Drug Combination Name
Picoplatin Terameprocol
Indication
Disease Entry Status REF
Adenocarcinoma Investigative [1]
Component Drugs Picoplatin   DM0PIY6 Terameprocol   DMC3P45
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: HCT-15
Zero Interaction Potency (ZIP) Score: 2.64
Bliss Independence Score: 3.97
Loewe Additivity Score: 1.33
LHighest Single Agent (HSA) Score: 1.26

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Picoplatin
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Phase 3 [2]
Ovarian cancer 2C73 Phase 3 [2]
Prostate cancer 2C82.0 Phase 3 [2]
Small-cell lung cancer 2C25.Y Phase 3 [2]
Indication(s) of Terameprocol
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Terameprocol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Transcription factor Sp1 (SP1) TTZEP6S SP1_HUMAN Modulator [3]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult T acute lymphoblastic leukemia DCET8R2 MOLT-4 Investigative [4]
Anaplastic large cell lymphoma DC78L8J SR Investigative [4]
Astrocytoma DCK58TP U251 Investigative [4]
Astrocytoma DC84PJ5 SNB-19 Investigative [4]
Childhood T acute lymphoblastic leukemia DCS640N CCRF-CEM Investigative [4]
Clear cell renal cell carcinoma DCAYZNM CAKI-1 Investigative [4]
Glioblastoma DCTWTFF SNB-75 Investigative [4]
Colon carcinoma DCA9WTM KM12 Investigative [5]
Adenocarcinoma DC06LX9 HT29 Investigative [1]
High grade ovarian serous adenocarcinoma DCSNOBC NCI\\/ADR-RES Investigative [1]
Lung adenocarcinoma DCL4GX3 NCI-H522 Investigative [1]
Malignant melanoma DC7V87N UACC62 Investigative [1]
Minimally invasive lung adenocarcinoma DCSZ3FB NCI-H322M Investigative [1]
Pleural epithelioid mesothelioma DCOCPP3 NCI-H226 Investigative [1]
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⏷ Show the Full List of 14 DrugCom(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 ClinicalTrials.gov (NCT00465491) Study of Picoplatin Efficacy After Relapse. U.S. National Institutes of Health.
3 Terameprocol, a novel site-specific transcription inhibitor with anticancer activity. IDrugs. 2008 Mar;11(3):204-14.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.