Details of the Drug Combination

General Information of Drug Combination (ID: DC966JR)

• Drug Combination Name: BIO-300 + Triiodothyronine
• Indication: Chronic myelogenous leukemia; Status: Investigative [1]
• Component Drugs:
  BIO-300 (DMJ7NVI): N.A.
  Triiodothyronine (DM14NKM): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: KBM-7
  Zero Interaction Potency (ZIP) Score: 3.09
  Bliss Independence Score: 3.09
  Loewe Additivity Score: 3.57
  LHighest Single Agent (HSA) Score: 3.64

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] Clinical pipeline report, company report or official report of Humanetics.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076923.
• [5] ClinicalTrials.gov (NCT04348513) Triiodothyronine for the Treatment of Critically Ill Patients With COVID-19 Infection. U.S. National Institutes of Health.