Details of the Drug Combination

General Information of Drug Combination (ID: DC9ISIN)

Drug Combination Name
Azithromycin Cefoxitin
Indication
Disease Entry Status REF
Endometritis Phase 2 [1]
Component Drugs Azithromycin   DMS6UOE Cefoxitin   DMY8NC4
Small molecular drug N.A.
2D MOL 2D MOL
3D MOL is unavailable 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Azithromycin
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis N.A. Approved [2]
Bronchitis CA20 Approved [3]
Chancroid N.A. Approved [2]
Mycoplasma pneumoniae pneumonia N.A. Approved [2]
Staphylococcus aureus infection N.A. Approved [2]
Streptococcal pneumonia N.A. Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [4]
Pneumonia caused by chlamydia N.A. Investigative [2]
Indication(s) of Cefoxitin
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis N.A. Approved [5]
Bacteremia 1A73 Approved [5]
Bacterial infection 1A00-1C4Z Approved [6]
Endometritis N.A. Approved [5]
Lung abscess N.A. Approved [5]
Peritonitis N.A. Approved [5]
Staphylococcal pneumonia N.A. Approved [5]
Staphylococcus aureus infection N.A. Approved [5]
Pelvic inflammatory disease GA05 Investigative [5]
Cefoxitin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Penicillin binding protein (Bact PBP) TTJP4SM NOUNIPROTAC Binder [7]
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Cefoxitin Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [8]
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Cefoxitin Interacts with 13 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Beta-lactamase (blaB) DEP0IWS A0A378EHS6_KLEPR Metabolism [9]
Beta-lactamase (blaB) DEEAL81 BLA2_KLEPO Metabolism [10], [11]
Beta-lactamase (blaB) DE7IH52 AMPC_CITFR Metabolism [12]
Beta-lactamase (blaB) DE5HV8P A0A4Q5I6I2_9BACE Metabolism [13]
Beta-lactamase (blaB) DE47ARF B5WXV2_9BACT Metabolism [13]
Beta-lactamase (blaB) DEHJVX4 A0A414C8Y0_9BACT Metabolism [13]
Beta-lactamase (blaB) DEG2PK9 B5WXV3_BACOV Metabolism [13]
Beta-lactamase (blaB) DEWHJ7A B5WXV7_BACT4 Metabolism [13]
Beta-lactamase (blaB) DEU1RXB BLAC_BACVU Metabolism [13]
Beta-lactamase (blaB) DEMIUB2 BLAT_ECOLX Metabolism [11]
Beta-lactamase (blaB) DEQAG48 A0A3Q9VXP1_CITAM Metabolism [14]
Beta-lactamase (blaB) DEF01WC A0A3S4HKA9_CHRVL Metabolism [15]
Beta-lactamase (blaB) DE5AHG6 BLAC_CITKO Metabolism [14]
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⏷ Show the Full List of 13 DME(s)
Cefoxitin Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
HLA class I histocompatibility antigen, A alpha chain (HLA-A) OTAH14LU HLAA_HUMAN Affects Expression [16]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Affects Expression [16]
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References

1 ClinicalTrials.gov (NCT03960970) Two-drug Antibiotic Prophylaxis in Scheduled Cesarean Deliveries
2 Azithromycin FDA Label
3 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 065511.
4 ClinicalTrials.gov (NCT04332107) Azithromycin for COVID-19 Treatment in Outpatients Nationwide. U.S. National Institutes of Health.
5 Cefoxitin FDA Label
6 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
7 Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains. Antimicrob Agents Chemother. 2008 Nov;52(11):3955-66.
8 Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
9 Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8.
10 Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. J Antimicrob Chemother. 1996 Sep;38(3):409-24.
11 Oral streptococcal strains isolated from odontogenic infections and their susceptibility to antibiotics. Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):1012-5.
12 Citrobacter freundii bacteremia: Risk factors of mortality and prevalence of resistance genes. J Microbiol Immunol Infect. 2018 Aug;51(4):565-572.
13 Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74.
14 Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent beta-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homology. J Antimicrob Chemother. 2004 Jun;53(6):1076-80.
15 Beta-lactamase activity in Chromobacterium violaceum. J Infect Dis. 1976 Sep;134(3):290-3.
16 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.