Details of the Drug Combination

General Information of Drug Combination (ID: DCA69Z7)

• Drug Combination Name: SY-1425 + Vinflunine
• Indication: Childhood T acute lymphoblastic leukemia; Status: Investigative [1]
• Component Drugs:
  SY-1425 (DMH8UF0): N.A.
  Vinflunine (DMTJAEP): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: CCRF-CEM
  Zero Interaction Potency (ZIP) Score: 13.58
  Bliss Independence Score: 14.86
  Loewe Additivity Score: 9.75
  LHighest Single Agent (HSA) Score: 9.89

Molecular Interaction Atlas of This Drug Combination

Indication(s) of SY-1425

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 1	[2]
Myelodysplastic syndrome	2A37	Phase 1	[2]

SY-1425 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Retinoic acid receptor alpha (RARA)	TTW38KT	RARA_HUMAN	Agonist	[2]

Indication(s) of Vinflunine

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Approved	[3]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCMXQGT	HL-60(TB)	Investigative	[1]
Adult T acute lymphoblastic leukemia	DCNMWLG	MOLT-4	Investigative	[1]
Astrocytoma	DC0ZOL9	U251	Investigative	[1]
Astrocytoma	DC475S3	SNB-19	Investigative	[1]
Chronic myelogenous leukemia	DCIM8MA	K-562	Investigative	[1]
Glioblastoma	DCKH99K	SNB-75	Investigative	[1]
Plasma cell myeloma	DCSXPKQ	RPMI-8226	Investigative	[1]
Renal cell carcinoma	DCZ4DXJ	SN12C	Investigative	[1]
Carcinoma	DC8N5UQ	MCF7	Investigative	[4]
Colon carcinoma	DCGHHUF	KM12	Investigative	[4]
Invasive ductal carcinoma	DCWKSPV	BT-549	Investigative	[4]
Adenocarcinoma	DC7IB28	OVCAR3	Investigative	[5]
Adenocarcinoma	DC5X5PH	HT29	Investigative	[5]
Cutaneous melanoma	DCGHP7R	SK-MEL-5	Investigative	[5]
High grade ovarian serous adenocarcinoma	DCUJYGX	OVCAR-8	Investigative	[5]
Lung adenocarcinoma	DC934VJ	HOP-62	Investigative	[5]
Malignant melanoma	DC5FO64	LOX IMVI	Investigative	[5]
Malignant melanoma	DCED3UH	UACC62	Investigative	[5]
Non-small cell lung carcinoma	DCVQRWN	HOP-92	Investigative	[5]
Pleural epithelioid mesothelioma	DCE77KE	NCI-H226	Investigative	[5]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [4] Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
• [5] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.