Details of the Drug Combination

General Information of Drug Combination (ID: DCA8U0C)

Drug Combination Name
Phenoxodiol Carboplatin
Indication
Disease Entry Status REF
Cancer Phase 1 [1]
Component Drugs Phenoxodiol   DMBUJVX Carboplatin   DMG281S
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Phenoxodiol
Disease Entry ICD 11 Status REF
Ovarian cancer 2C73 Phase 1/2 [2]
Phenoxodiol Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
X-linked inhibitor of apoptosis protein (XIAP) TTR7B60 XIAP_HUMAN Modulator [6]
Sphingosine kinase 1 (SPHK1) TTOHFIY SPHK1_HUMAN Modulator [6]
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Phenoxodiol Interacts with 3 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Activity [5]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Activity [5]
Ecto-NOX disulfide-thiol exchanger 2 (ENOX2) OTMDA97Z ENOX2_HUMAN Decreases Activity [7]
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Indication(s) of Carboplatin
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [3]
Carcinoma 2A00-2F9Z Approved [3]
Cholangiocarcinoma 2C12.10 Approved [3]
Cutaneous melanoma 2C30 Approved [3]
Epithelial ovarian cancer 2B5D Approved [3]
Fallopian tube neoplasm N.A. Approved [3]
Gastroesophageal junction adenocarcinoma 2B71 Approved [3]
Lung adenocarcinoma N.A. Approved [3]
Lung cancer 2C25.0 Approved [3]
Non-small-cell lung cancer 2C25.Y Approved [3]
Ovarian cancer 2C73 Approved [4]
Ovarian disorder N.A. Approved [3]
Ovarian neoplasm N.A. Approved [3]
Ovarian serous cystadenocarcinoma N.A. Approved [3]
Small-cell lung cancer 2C25.Y Approved [3]
Lung large cell carcinoma N.A. Investigative [3]
Neuroblastoma 2D11.2 Investigative [3]
Carboplatin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Modulator [8]
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Carboplatin Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
High affinity copper uptake protein 1 (SLC31A1) DTP8L4F COPT1_HUMAN Substrate [9]
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Carboplatin Interacts with 7 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Glutathione S-transferase pi (GSTP1) DEK6079 GSTP1_HUMAN Metabolism [10]
Glutathione S-transferase theta-1 (GSTT1) DE3PKUG GSTT1_HUMAN Metabolism [10]
Metallothionein-1A (MT1A) DE5ME8A MT1A_HUMAN Metabolism [10]
Metallothionein-2A (MT2A) DEFKGT7 MT2_HUMAN Metabolism [10]
Myeloperoxidase (MPO) DEA3U9Y PERM_HUMAN Metabolism [10]
Quinone reductase 1 (NQO1) DENP5RY NQO1_HUMAN Metabolism [10]
Glutathione S-transferase mu-1 (GSTM1) DEYZEJA GSTM1_HUMAN Metabolism [10]
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⏷ Show the Full List of 7 DME(s)

References

1 ClinicalTrials.gov (NCT02941523) Safety, PK and Efficacy of NOX66 as a Monotherapy and Combined With Carboplatin in Refractory Solid Tumours
2 ClinicalTrials.gov (NCT00382811) OVATURE (OVArian TUmor REsponse) A Phase III Study of Weekly Carboplatin With and Without Phenoxodiol in Patients With Platinum-Resistant, Recurrent Epithelial Ovarian Cancer. U.S. National Institutes of Health.
3 Carboplatin FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7624).
5 Molecular mechanism of phenoxodiol-induced apoptosis in ovarian carcinoma cells. Cancer. 2006 Feb 1;106(3):599-608. doi: 10.1002/cncr.21633.
6 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
7 Reciprocal relationship between cytosolic NADH and ENOX2 inhibition triggers sphingolipid-induced apoptosis in HeLa cells. J Cell Biochem. 2010 Aug 15;110(6):1504-11. doi: 10.1002/jcb.22724.
8 Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.Clin Cancer Res.2010 Oct 1;16(19):4899-905.
9 Overcoming platinum drug resistance with copper-lowering agents. Anticancer Res. 2013 Oct;33(10):4157-61.
10 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)