Details of the Drug Combination

General Information of Drug Combination (ID: DCAUZ28)

Drug Combination Name
Articaine Benzocaine
Indication
Disease Entry Status REF
Anesthesia of Mucous Membrane Phase 4 [1]
Component Drugs Articaine   DM3NMT6 Benzocaine   DMI18HW
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Articaine
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [2]
Indication(s) of Benzocaine
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [3]
Cough MD12 Approved [4]
Tinea corporis 1F28.Y Approved [5]
Pruritus EC90 Investigative [6]
Tinea infection N.A. Investigative [5]
Tinea pedis 1F28.2 Investigative [5]
Benzocaine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Blocker [7]
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Benzocaine Interacts with 5 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Increases Expression [8]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [9]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Phosphorylation [9]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [9]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Increases Expression [9]
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References

1 ClinicalTrials.gov (NCT01951820) Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Double-blind, randomized, placebo-controlled clinical trials with non-prescription medications for the treatment of obesity. Obes Res. 1999 Jul;7(4):370-8.
4 Benzocaine. 2021 Oct 18. Drugs and Lactation Database (LactMed?) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006C.
5 Benzocaine: Review on a Drug with Unfold Potential. Mini Rev Med Chem. 2020;20(1):3-11.
6 A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain. J Dermatolog Treat. 2015;26(4):367-72.
7 Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circ Res. 2008 Jan 4;102(1):86-94.
8 Suitability of macrophage inflammatory protein-1beta production by THP-1 cells in differentiating skin sensitizers from irritant chemicals. Contact Dermatitis. 2008 Apr;58(4):193-8. doi: 10.1111/j.1600-0536.2007.01311.x.
9 Nicotine-induced autophagy via AMPK/mTOR pathway exerts protective effect in colitis mouse model. Chem Biol Interact. 2020 Feb 1;317:108943. doi: 10.1016/j.cbi.2020.108943. Epub 2020 Jan 10.