Details of the Drug Combination

General Information of Drug Combination (ID: DCCTGA6)

Drug Combination Name
Degarelix Leuprolide
Indication
Disease Entry Status REF
Metastatic Castration Sensitive Prostate Cancer (mCSPC) Phase 1 [1]
Component Drugs Degarelix   DM3O8QY Leuprolide   DM5XPIJ
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Degarelix
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [2]
Degarelix Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Gonadotropin-releasing hormone receptor (GNRHR) TT8R70G GNRHR_HUMAN Inhibitor [5]
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Indication(s) of Leuprolide
Disease Entry ICD 11 Status REF
Plasma cell myeloma 2A83.1 Approved [3]
Prostate cancer 2C82.0 Approved [4]
Endometriosis GA10 Investigative [3]
Leuprolide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Leutinizing-hormone-releasing hormone (GNRH1) TT0ID4A GON1_HUMAN Activator [6]
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Leuprolide Interacts with 3 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Thyroxine-binding globulin (SERPINA7) OTUYVTSU THBG_HUMAN Increases ADR [7]
Thyroid peroxidase (TPO) OTJJLL20 PERT_HUMAN Increases ADR [7]
Protein bric-a-brac 2 (bab2) OTNNK0KI BAB2_DROME Increases ADR [7]
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References

1 ClinicalTrials.gov (NCT05701007) Real World Evidence Study on Metastatic Prostate Cancer in the Pirkanmaa Hospital District in Finland
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5585).
3 Leuprolide FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1175).
5 Iterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7, and 8. Part II. J Med Chem. 2005 Jul 28;48(15):4851-60.
6 Increased risk of metabolic syndrome, diabetes mellitus, and cardiovascular disease in men receiving androgen deprivation therapy for prostate cancer. Pharmacotherapy. 2008 Dec;28(12):1511-22.
7 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.