Details of the Drug Combination

General Information of Drug Combination (ID: DCDGS04)

Drug Combination Name
Deferiprone Acetylcysteine
Indication
Disease Entry Status REF
Diabetes Mellitus Phase 2 [1]
Component Drugs Deferiprone   DMS2M7O Acetylcysteine   DMWSXI4
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Deferiprone
Disease Entry ICD 11 Status REF
Beta thalassemia 3A50.2 Approved [2]
Iron overload disease 5C64.10 Approved [2]
Thalassemia 3A50 Approved [3]
Deferiprone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Iron (Fe) TTUDR0C NOUNIPROTAC Modulator [6]
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Deferiprone Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
UDP-glucuronosyltransferase 1A6 (UGT1A6) DESD26P UD16_HUMAN Metabolism [7]
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Deferiprone Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Frataxin, mitochondrial (FXN) OTE9U09A FRDA_HUMAN Increases Expression [8]
Serotransferrin (TF) OT41PEMS TRFE_HUMAN Increases Expression [9]
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Indication(s) of Acetylcysteine
Disease Entry ICD 11 Status REF
Amyloidosis 5D00 Approved [4]
Bronchiectasis CA24 Approved [4]
Bronchitis CA20 Approved [4]
Bulimia nervosa 6B81 Approved [4]
Ischemia-reperfusion injury DB98.B Approved [4]
Liver disease DB90-BD99 Approved [5]
Paracetamol poisoning N.A. Approved [4]

References

1 ClinicalTrials.gov (NCT02882477) Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy
2 Deferiprone FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7456).
4 Acetylcysteine FDA Label
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
7 Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants. Drug Metab Dispos. 2009 Feb;37(2):322-9.
8 Pharmacological screening using an FXN-EGFP cellular genomic reporter assay for the therapy of Friedreich ataxia. PLoS One. 2013;8(2):e55940.
9 Antiproliferative effect of deferiprone on the Hep G2 cell line. Biochem Pharmacol. 1998 Aug 15;56(4):431-7. doi: 10.1016/s0006-2952(98)00071-9.