Details of the Drug Combination

General Information of Drug Combination (ID: DCDXRKC)

Drug Combination Name
Proparacaine Pilocarpine
Indication
Disease Entry Status REF
Glaucoma, Angle-Closure Phase 1 [1]
Component Drugs Proparacaine   DMLS39E Pilocarpine   DMV9ADG
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Proparacaine
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [2]
Proparacaine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Voltage-gated sodium channel alpha Nav1.8 (SCN10A) TT90XZ8 SCNAA_HUMAN Modulator [5]
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Indication(s) of Pilocarpine
Disease Entry ICD 11 Status REF
Glaucoma/ocular hypertension 9C61 Approved [3]
Ocular hypertension 9C61.01 Approved [4]
Pilocarpine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Muscarinic acetylcholine receptor M5 (CHRM5) TTH18TF ACM5_HUMAN Agonist [6]
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Pilocarpine Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [7]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Metabolism [8]
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Pilocarpine Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Delta-type opioid receptor (OPRD1) OT164PA1 OPRD_HUMAN Increases ADR [9]
Mu-type opioid receptor (OPRM1) OT16AAT8 OPRM_HUMAN Increases ADR [9]
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References

1 ClinicalTrials.gov (NCT02613013) Laser Peripheral Iridotomy Plus Laser Peripheral Iridoplasty for Primary Angle Closure
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7283).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 305).
4 Pilocarpine FDA Label
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L340-6.
7 The inhibition of CYP enzymes in mouse and human liver by pilocarpine. Br J Pharmacol. 1995 Feb;114(4):832-6.
8 Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine. FEBS J. 2012 May;279(9):1621-31.
9 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.