Details of the Drug Combination

General Information of Drug Combination (ID: DCEC1K4)

• Drug Combination Name: Pentostatin + Phensuximide
• Indication: Chronic myelogenous leukemia; Status: Investigative [1]
• Component Drugs:
  Pentostatin (DM0HXDS): Small molecular drug
  Phensuximide (DMFGLXB): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: KBM-7
  Zero Interaction Potency (ZIP) Score: 7.57
  Bliss Independence Score: 7.57
  Loewe Additivity Score: 21.3
  LHighest Single Agent (HSA) Score: 21.3

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Pentostatin

Disease Entry	ICD 11	Status	REF
Acute graft versus host disease	4B24.0	Approved	[2]
Hairy cell leukaemia	2A82.2	Approved	[3]
Leukemia	N.A.	Approved	[2]

Pentostatin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Adenosine deaminase (ADA)	TTLP57V	ADA_HUMAN	Inhibitor	[6]

Indication(s) of Phensuximide

Disease Entry	ICD 11	Status	REF
Absence epilepsy	N.A.	Approved	[4]
Epilepsy	8A60-8A68	Approved	[4]
Seizure disorder	8A6Z	Approved	[5]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] Pentostatin FDA Label
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4805).
• [4] Phensuximide FDA Label
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7612).
• [6] Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.